ReviewJournal of the American Society of Hypertension : JASH
The mosaic theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension.
Review in Journal of the American Society of Hypertension : JASH. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Blood pressure trajectories and the mediated effects of body mass index and HIV-related inflammation in a mixed cohort of people with and without HIV in rural Uganda.Journal of clinical hypertension (Greenwich, Conn.) · 2019Trial
- Unveiling the impact of colonic pH and pH-sensing receptors in blood pressure regulation.Gut microbes · 2026Review
- Review
- Sex-dependent differences in mitochondrial protein acetylation in metabolic condition, oxidative stress, vascular dysfunction, hypertension, and cardiovascular disease.Clinical science (London, England : 1979) · 2026Review
- Six Weeks of Boxing Training Lowers Blood Pressure and Improves Vascular Function in Young Men and Women with Elevated Blood Pressure or Stage 1 Hypertension.Sports (Basel, Switzerland) · 2026Article
- Sleep disturbance and hypertension mediated by systemic inflammatory response index in NHANES.Scientific reports · 2025Article
- Depletion of Mitochondrial Cyclophilin D in Endothelial and Smooth Muscle Cells Attenuates Vascular Dysfunction and Hypertension.Function (Oxford, England) · 2025Article
- Association of the systemic immune-inflammation index with clinical outcomes in acute myocardial infarction patients with hypertension.BMC immunology · 2025Article
- Effect of Short-Term Restraint Stress on the Expression of Genes Associated with the Response to Oxidative Stress in the Hypothalamus of Hypertensive ISIAH and Normotensive WAG Rats.Antioxidants (Basel, Switzerland) · 2024Article
- Hypertensive Heart Failure.Journal of clinical medicine · 2023Review
- Mechanisms of Oxidative Stress in Metabolic Syndrome.International journal of molecular sciences · 2023Review
- Protective effects of melatonin on myocardial microvascular endothelial cell injury under hypertensive state by regulating Mst1.BMC cardiovascular disorders · 2023Article
- Systemic inflammation markers and the prevalence of hypertension: A NHANES cross-sectional study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Microglia-mediated inflammatory destruction of neuro-cardiovascular dysfunction after stroke.Frontiers in cellular neuroscience · 2023Review
- Adipokines: Deciphering the cardiovascular signature of adipose tissue.Biochemical pharmacology · 2022Review
- Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron.American journal of physiology. Cell physiology · 2022Article
- Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects.Acta pharmacologica Sinica · 2022Article
- Non-invasive myocardial work index contributes to early identification of impaired left ventricular myocardial function in uremic patients with preserved left ventricular ejection fraction.Biomedical engineering online · 2022Article
- Molecular Interactions of Arterial Hypertension in Its Target Organs.International journal of molecular sciences · 2021Review
- Fumarate exerted an antihypertensive effect and reduced kidney injury molecule (KIM)-1 expression in deoxycorticosterone acetate-salt hypertension.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
More than 60 years ago, Dr. Irvine Page proposed the Mosaic Theory of hypertension, which states that many factors, including genetics, environment, adaptive, neural, mechanical, and hormonal perturbations interdigitate to raise blood pressure. In the past two decades, it has become clear that common molecular and cellular events in various organs underlie many features of the Mosaic Theory. Two of these are the production of reactive oxygen species and inflammation. These factors increase neuronal firing in specific brain centers, increase sympathetic outflow, alter vascular tone and morphology, and promote sodium retention in the kidney. Moreover, factors such as genetics and environment contribute to oxidant generation and inflammation. Other common cellular signals, including calcium signaling and endoplasmic reticulum stress are similarly perturbed in different cells in hypertension and contribute to components of Page's theory. Thus, Page's Mosaic Theory formed a framework for future studies of molecular and cellular signals in the context of hypertension, and has greatly aided our understanding of this complex disease.
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