ArticleThe American journal of pathology2013
Alterations in glucose homeostasis in a murine model of Chagas disease.
Article in The American journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Decreased Insulin Levels in Patients with Acute Chagas Disease from Brazilian Amazon treated with Benznidazole.Arquivos brasileiros de cardiologia · 2025Article
- Influence of a hyperglycaemic diet on Trypanosoma cruzi infection in mice model.Memorias do Instituto Oswaldo Cruz · 2025Article
- Echoes of the Past: The Intriguing Link between Chagas Disease and Insulin.Arquivos brasileiros de cardiologia · 2025Article
- Small molecule mediators of host-T. cruzi-environment interactions in Chagas disease.PLoS pathogens · 2024Review
- DIAGNOSIS AND TREATMENT OF A NATURAL INFECTION WITHJournal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians · 2023Article
- Diets Differently Regulate Tumorigenesis in Young E0771 Syngeneic Breast Cancer Mouse Model.Journal of clinical medicine · 2023Article
- Functional Autoreactive Anti-β2 Adrenergic Antibodies May Contribute to Insulin Resistance Profile in Patients with Chronic Chagas Disease.Pathogens (Basel, Switzerland) · 2021Article
- Metabolic syndrome agravates cardiovascular, oxidative and inflammatory dysfunction during the acute phase of Trypanosoma cruzi infection in mice.Scientific reports · 2019Article
- Exploring pancreatic pathology in Plasmodium falciparum malaria patients.Scientific reports · 2018Article
- Limited Foxp3Frontiers in immunology · 2018Article
- Pathogen manipulation of host metabolism: A common strategy for immune evasion.PLoS pathogens · 2017Review
- Modulation of host central carbon metabolism and in situ glucose uptake by intracellular Trypanosoma cruzi amastigotes.PLoS pathogens · 2017Article
- Adipose Tissue: A Safe Haven for Parasites?Trends in parasitology · 2017Review
- Alterations in pancreatic β cell function and Trypanosoma cruzi infection: evidence from human and animal studies.Parasitology research · 2017Review
- Antagonistic effect of atorvastatin on high fat diet induced survival during acute Chagas disease.Microbes and infection · 2016Article
- Article
- The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice.Diabetes/metabolism research and reviews · 2015Article
- The cell biology of fat expansion.The Journal of cell biology · 2015Review
- Trypanosoma cruzi infection is a potent risk factor for non-alcoholic steatohepatitis enhancing local and systemic inflammation associated with strong oxidative stress and metabolic disorders.PLoS neglected tropical diseases · 2015Article
- Dysregulation of Autonomic Nervous System in Chagas' Heart Disease Is Associated with Altered Adipocytokines Levels.PloS one · 2015Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 5 countries.
Funding
Abstract
Chagas disease, caused by Trypanosoma cruzi, is an important cause of morbidity and mortality primarily resulting from cardiac dysfunction, although T. cruzi infection results in inflammation and cell destruction in many organs. We found that T. cruzi (Brazil strain) infection of mice results in pancreatic inflammation and parasitism within pancreatic β-cells with apparent sparing of α cells and leads to the disruption of pancreatic islet architecture, β-cell dysfunction, and surprisingly, hypoglycemia. Blood glucose and insulin levels were reduced in infected mice during acute infection and insulin levels remained low into the chronic phase. In response to the hypoglycemia, glucagon levels 30 days postinfection were elevated, indicating normal α-cell function. Administration of L-arginine and a β-adrenergic receptor agonist (CL316, 243, respectively) resulted in a diminished insulin response during the acute and chronic phases. Insulin granules were docked, but the lack of insulin secretion suggested an inability of granules to fuse at the plasma membrane of pancreatic β-cells. In the liver, there was a concomitant reduced expression of glucose-6-phosphatase mRNA and glucose production from pyruvate (pyruvate tolerance test), demonstrating defective hepatic gluconeogenesis as a cause for the T. cruzi-induced hypoglycemia, despite reduced insulin, but elevated glucagon levels. The data establishes a complex, multi-tissue relationship between T. cruzi infection, Chagas disease, and host glucose homeostasis.
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Registered trials
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