ArticleJournal of endodontics2013
Biofilm formation within the interface of bovine root dentin treated with conjugated chitosan and sealer containing chitosan nanoparticles.
Article in Journal of endodontics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 89 citations in OpenAlex.
- Scoping review on the genotoxicity of silver nanoparticles in endodontics: therapeutic saviors or genetic saboteurs?Odontology · 2025Article
- Antimicrobial efficacy of modified gutta-percha for obturation - A systematic review.Journal of conservative dentistry and endodontics · 2025Review
- Review
- Article
- Application of Nanomaterials in Endodontics.BME frontiers · 2024Review
- Nanoparticles and Their Antibacterial Application in Endodontics.Antibiotics (Basel, Switzerland) · 2023Review
- Antibacterial Activity of Root Repair Cements in Contact with Dentin-An Ex Vivo Study.Journal of functional biomaterials · 2023Article
- Evaluation of Smear Layer Removal and Micro Hardness Alteration of Radicular Dentin after Using Various Chelating Agents - An Atomic Force Microscopic Study.Journal of pharmacy & bioallied sciences · 2023Article
- Antimicrobial and Antibiofilm Properties of Bioceramic Materials in Endodontics.Materials (Basel, Switzerland) · 2021Review
- Functionalized Nanoparticles Activated by Photodynamic Therapy as an Antimicrobial Strategy in Endodontics: A Scoping Review.Antibiotics (Basel, Switzerland) · 2021Article
- Engineering Polymeric Nanosystems against Oral Diseases.Molecules (Basel, Switzerland) · 2021Review
- Chitosan-Based Biomaterial, Calcium Hydroxide and Chlorhexidine for Potential Use as Intracanal Medication.Materials (Basel, Switzerland) · 2021Article
- The Potential Translational Applications of Nanoparticles in Endodontics.International journal of nanomedicine · 2021Review
- Post-treatment Flare-up Incidence after Using Nano Zinc Oxide Eugenol Sealer in Mandibular First Molars with Irreversible Pulpitis.Journal of dentistry (Shiraz, Iran) · 2020Article
- Effectiveness of chitosan-propolis nanoparticle against Enterococcus faecalis biofilms in the root canal.BMC oral health · 2020Article
- Comparative effects of final canal irrigation with chitosan and EDTA.Journal of applied oral science : revista FOB · 2020Article
- Antibacterial Additives in Epoxy Resin-Based Root Canal Sealers: A Focused Review.Dentistry journal · 2019Review
- Discoloration of teeth due to different intracanal medicaments.Restorative dentistry & endodontics · 2019Article
- Bacterial colonization in the apical part of extracted human teeth following root-end resection and filling: a confocal laser scanning microscopy study.Clinical oral investigations · 2018Article
- Nanotechnology-based drug delivery systems for control of microbial biofilms: a review.International journal of nanomedicine · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
introductionThe purpose of this study was to assess biofilm formation within sealer-dentin interfaces of root segments filled with gutta-percha and sealer incorporated with chitosan (CS) nanoparticles with and without canal surface treatment with different formulations of CS.
methodsStandardized canals of 4-mm bovine root segments (N = 35) were filled with gutta-percha and pulp canal sealer incorporated with CS nanoparticles without surface treatment (group CS) or after surface treatment with phosphorylated CS (group PHCS), CS-conjugated rose bengal and photodynamic irradiation (group CSRB), or a combination of both PHCS and CSRB (group RBPH). The control group was filled with gutta-percha and an unmodified sealer. After 7 days of setting, specimens were aged in buffered solution at 37°C for 1 or 4 weeks. Monospecies biofilms of Enterococcus faecalis were grown on specimens for 7 days in a chemostat-based biofilm fermentor. Biofilm formation within the sealer-dentin interface was assessed with confocal laser scanning microscopy.
resultsIn the 4-week-aged specimens only, the mean biofilm areas were significantly smaller than in the control for the CS (P = .008), PHCS (P = .012), and RBPH (P = .034) groups. The percentage of the biofilm-covered interface also was significantly lower than in the control for the CS (P = .024) and PHCS (P = .003) groups. The CS, PHCS, and RBPH groups did not differ significantly.
conclusionsIncorporating CS nanoparticles into the zinc oxide-eugenol sealer inhibited biofilm formation within the sealer-dentin interface. This effect was maintained when canals were treated with phosphorylated CS, and it was moderated by canal treatment with CS-conjugated rose bengal and irradiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.