ArticleTransfusion2013
Blood transfusions and the subsequent risk of cancers in the United States elderly.
Article in Transfusion, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- [Safety of cell salvage in tumor surgery : Systematic review with meta-analysis].Der Anaesthesist · 2020Pooled it
- Medical history, lifestyle, family history, and occupational risk factors for adult acute lymphocytic leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.Journal of the National Cancer Institute. Monographs · 2014Pooled it
- Assessing the relationship between blood transfusion products and non-Hodgkin's lymphoma incidence: A longitudinal retrospective cohort study (2004-2022).Journal of family medicine and primary care · 2025Article
- Blood transfusions may adversely affect survival outcomes of patients with lung cancer: a systematic review and meta-analysis.Translational lung cancer research · 2021Article
- Article
- Peripartum Blood Transfusions are Associated with Increased Risk of Cancer: A National Retrospective Cohort Study.Clinical epidemiology · 2020Article
- Blood Transfusion and the Risk of Cancer in the US Population: Is There an Association?Clinical epidemiology · 2020Article
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- Cancer risk among 21st century blood transfusion recipients.Annals of oncology : official journal of the European Society for Medical Oncology · 2017Article
- On the use and misuse of scalar scores of confounders in design and analysis of observational studies.Statistics in medicine · 2015Article
- Cost of post-operative intravenous iron therapy in total lower limb arthroplasty: a retrospective, matched cohort study.Blood transfusion = Trasfusione del sangue · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBlood transfusions are common in older adults and also may modulate the immune system. However, the impact of transfusion on cancer risk in the elderly has not been studied. STUDY DESIGN AND
methodsCancer risk after blood transfusion was evaluated in a US population-based case-control study using 552,951 elderly cases identified from cancer registries and 100,000 frequency-matched controls. Transfusions received 0 to 12, 13 to 30, and 31 to 48 months before cancer diagnosis or selection date were identified using Medicare claims. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. A Bonferroni correction adjusted for multiple testing.
resultsTransfusions received 0 to 12 months before cancer diagnosis and/or selection were associated with significantly elevated risk of cancer overall (OR,2.05; 95% CI, 1.95-2.16) and cancer of the stomach; cancer of the colon; cancer of the liver, kidney, renal pelvis, and/or ureter; lymphoma; myeloma; and leukemia. No significant associations for cancer overall were observed for the two earlier intervals. No site was associated with transfusions received 13 to 30 or 31 to 48 months before diagnosis and/or selection. Nonetheless, overall cancer risk increased with the number of transfused periods (p-trend<0.0001).
conclusionRisk of overall cancer and specific sites was elevated 0 to 12 months after blood transfusion and associated with multiple transfusions, possibly due to reverse causation, that is, incipient cancers or cancer precursors causing anemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.