ArticleJournal of the American Geriatrics Society2013
Ten-year trajectory of potentially inappropriate medications in very old women: importance of cognitive status.
Article in Journal of the American Geriatrics Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 10 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- The Prognostic Utility of Anticholinergic Burden Scales: An Integrative Review and Gap Analysis.Drugs & aging · 2023Pooled it
- Global prevalence of polypharmacy and potentially inappropriate medication in older patients with dementia: a systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Quality of anticholinergic burden scales and their impact on clinical outcomes: a systematic review.European journal of clinical pharmacology · 2021Pooled it
- Association between anticholinergic (atropinic) drug exposure and cognitive function in longitudinal studies among individuals over 50 years old: a systematic review.European journal of clinical pharmacology · 2019Pooled it
- Factors associated with potentially inappropriate medication use in community-dwelling older adults in the United States: a systematic review.The International journal of pharmacy practice · 2019Pooled it
- Identifying potentially inappropriate prescribing in older people with dementia: a systematic review.European journal of clinical pharmacology · 2019Pooled it
- Anticholinergic Drug Burden Tools/Scales and Adverse Outcomes in Different Clinical Settings: A Systematic Review of Reviews.Drugs & aging · 2018Pooled it
- Use of Benzodiazepines in Alzheimer's Disease: A Systematic Review of Literature.The international journal of neuropsychopharmacology · 2015Pooled it
- Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review.BMC geriatrics · 2015Pooled it
- Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review.Current clinical pharmacology · 2015Pooled it
- Anticholinergic exposure and cognitive decline in older adults: effect of anticholinergic exposure definitions in a 3-year analysis of the multidomain Alzheimer preventive trial (MAPT) study.British journal of clinical pharmacology · 2019Trial
- Trajectories of potentially inappropriate medication use among older adults in Saudi Arabia.Frontiers in pharmacology · 2025Article
- Benzodiazepine-Receptor Agonist Utilization in Outpatients with Anxiety Disorder: A Retrospective Study Based on Electronic Healthcare Data from a Large General Tertiary Hospital.Healthcare (Basel, Switzerland) · 2023Article
- Polypharmacy among older adults with dementia compared with those without dementia in the United States.Journal of the American Geriatrics Society · 2021Article
- The inappropriate use of proton pump inhibitors and its associated factors among community-dwelling older adults.Heliyon · 2021Article
- Trends in the consumption rates of benzodiazepines and benzodiazepine-related drugs in the health region of Lleida from 2002 to 2015.BMC public health · 2020Article
- Drug related problems in older adults living with dementia.PloS one · 2020Article
- Temporal Trends in the Use of Anticholinergic Drugs Among Older People Living in Long-Term Care Facilities in Helsinki.Drugs & aging · 2020Article
- The relationship of severity of symptoms of depression, anxiety, and stress with sleep quality in earthquake survivors in Kermanshah.Journal of injury & violence research · 2019Article
- Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia.European journal of clinical pharmacology · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesTo determine which older adults tend to receive potentially inappropriate medications (PIMs), how this may differ according to cognitive status, and how the trajectories of PIM use change over time.
designTen-year longitudinal cohort study.
settingThree clinical sites in the United States.
participantsOne thousand four hundred eighty-four community-dwelling women aged 75 and older. MEASUREMENTS: At follow-up, cognitive status was ascertained and classified as normal, mild cognitive impairment (MCI), or dementia. Beers 2003 criteria and other literature were used to identify PIMs from detailed medication inventory performed at three time points. Anticholinergic load was measured using the Anticholinergic Cognitive Burden Scale (ACB), which assigns medications a value from 0 to 3 depending on anticholinergic properties.
resultsAt baseline, 23.9% of women were taking at least one PIM and the mean ± SD ACB score was 1.41 ± 1.69. The most frequently reported PIMs were anticholinergics (15.2%), benzodiazepines (8.6%), and antispasmodics (8.0%). Over 10 years, PIM use increased for women with dementia (24.9-33.1%; P = .02) but remained fairly constant for women with MCI (23.9-23.0%; P = .84) and normal cognitive status (22.2-19.8%; P = .17). Mean ACB score increased significantly (P < .001) over time for all groups (dementia: 1.28-2.05; MCI: 0.98-1.66; normal: 0.99-1.48).
conclusionPIM use and anticholinergic load in a community-dwelling population of older women was high, especially in women who later developed dementia. Future guidelines should limit PIM use and seek safer alternatives.
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