ArticleBJU international2013
Clinical implications of family history of prostate cancer and genetic risk single nucleotide polymorphism (SNP) profiles in an active surveillance cohort.
Article in BJU international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Research status and hotspots of oncology genetic nursing: a bibliometric analysis.Frontiers in oncology · 2025Pooled it
- Impact of family history of prostate cancer on disease progression for prostatic cancer patients undergoing active surveillance: A systematic review and meta-analysis.Investigative and clinical urology · 2024Pooled it
- Active surveillance for intermediate-risk prostate cancer.Prostate cancer and prostatic diseases · 2017Pooled it
- Active surveillance for prostate cancer: a systematic review of clinicopathologic variables and biomarkers for risk stratification.European urology · 2015Pooled it
- Genetic variants of the Wnt signaling pathway as predictors of aggressive disease and reclassification in men with early stage prostate cancer on active surveillance.Carcinogenesis · 2016Trial
- Impact of an Expanded Definition of Family History on Outcomes of Active Surveillance for Prostate Cancer.The Journal of urology · 2023Article
- Complexities of Prostate Cancer.International journal of molecular sciences · 2022Review
- Association of prostate cancer polygenic risk score with number and laterality of tumor cores in active surveillance patients.The Prostate · 2021Article
- Prostate cancer.Nature reviews. Disease primers · 2021Review
- Personalized Decision Making for Biopsies in Prostate Cancer Active Surveillance Programs.Medical decision making : an international journal of the Society for Medical Decision Making · 2019Article
- Post-GWAS in prostate cancer: from genetic association to biological contribution.Nature reviews. Cancer · 2019Review
- Systematic identification of functionally relevant risk alleles to stratify aggressive versus indolent prostate cancer.Oncotarget · 2018Article
- How Sensitive Is Genetic Data?Biopreservation and biobanking · 2017Article
- Prostate Cancer: Is It a Battle Lost to Age?Geriatrics (Basel, Switzerland) · 2016Review
- The PROFILE Feasibility Study: Targeted Screening of Men With a Family History of Prostate Cancer.The oncologist · 2016Article
- Associations Between iCOGS Single Nucleotide Polymorphisms and Upgrading in Both Surgical and Active Surveillance Cohorts of Men with Prostate Cancer.European urology · 2016Article
- Multiplex pyrosequencing assay using AdvISER-MH-PYRO algorithm: a case for rapid and cost-effective genotyping analysis of prostate cancer risk-associated SNPs.BMC medical genetics · 2015Article
- The genetic epidemiology of prostate cancer and its clinical implications.Nature reviews. Urology · 2014Review
- Genome-wide association studies on prostate cancer: the end or the beginning?Protein & cell · 2013Review
- Genetic and molecular differences in prostate carcinogenesis between African American and Caucasian American men.International journal of molecular sciences · 2013Review
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Authors and funding
22 authors.
Funding
Abstract
objectivesTo explore the potential prognostic role of family history (FH) of prostate cancer and prostate cancer risk single nucleotide polymorphisms (SNPs) in patients undergoing active surveillance (AS) for prostate cancer. This is the first study to date, which has investigated the potential prognostic role of SNP profiles in an AS cohort PATIENTS AND
methodsFH data were collected from patients in the Royal Marsden Hospital AS study. In all, 39 prostate cancer-risk SNPs identified from published genome wide association studies (GWAS) were genotyped using the Sequenom Platform and TaqMan™ assays from available DNA. The cumulative genetic-risk scores for each patient were then calculated using the weighted effect estimated from previous GWAS (log-additive model). FH status and the genetic-risk scores were assessed against adverse outcomes in AS, time to treatment and adverse histology on repeat biopsy, using univariable and multivariable Cox regression models to address time to treatment; and binary logistic regression to address biopsy upgrade.
resultsOf 471 patients, 55 (13.6%) had adverse histology on repeat biopsies and 145 (30.8%) had deferred treatment. On univariate analysis, there was no significant relationship between FH of prostate cancer in any degree of relation, and adverse histology or time to treatment. For risk score analyses, 386 patients' DNA was studied; and there was also no relationship found between the calculated genetic risk scores and adverse histology or time to treatment (P = 0.573 and P = 0.965, respectively). The retrospective study design and the few events were the main limitation of the study.
conclusionsThere is currently insufficient data to support the use of FH status or prostate cancer SNP profile risk scores as prognostic factors in AS and these should not be used to influence management decisions. As more genetic variants are discovered this may change and should be reassessed in multicentre AS cohorts.
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