ReviewCurrent gene therapy2013
Translating induced pluripotent stem cells from bench to bedside: application to retinal diseases.
Review in Current gene therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Chemically induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells.Stem cells translational medicine · 2014Trial
- Biophysical, Molecular and Proteomic Profiling of Human Retinal Organoid-Derived Exosomes.Pharmaceutical research · 2023Article
- Stem cell transplantation as a progressing treatment for retinitis pigmentosa.Cell and tissue research · 2022Review
- Retina stem cells, hopes and obstacles.World journal of stem cells · 2021Review
- Transplanted embryonic retinal stem cells have the potential to repair the injured retina in mice.BMC ophthalmology · 2021Article
- Novel Programmed Cell Death as Therapeutic Targets in Age-Related Macular Degeneration?International journal of molecular sciences · 2020Review
- Repair of Retinal Degeneration following Ex Vivo Minicircle DNA Gene Therapy and Transplantation of Corrected Photoreceptor Progenitors.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- Human Induced Pluripotent Stem Cells : Clinical Significance and Applications in Neurologic Diseases.Journal of Korean Neurosurgical Society · 2019Article
- BAM15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.Stem cell research & therapy · 2019Article
- CRISPR GENOME SURGERY IN THE RETINA IN LIGHT OF OFF-TARGETING.Retina (Philadelphia, Pa.) · 2018Review
- Generation of Retinal Organoids with Mature Rods and Cones from Urine-Derived Human Induced Pluripotent Stem Cells.Stem cells international · 2018Article
- Establishing a Surgical Procedure for Rhesus Epiretinal Scaffold Implantation with HiPSC-Derived Retinal Progenitors.Stem cells international · 2018Article
- Electronic retinal implant surgery.Eye (London, England) · 2017Article
- Glycosylation and stem cells: Regulatory roles and application of iPSCs in the study of glycosylation-related disorders.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Gene Therapy and Stem Cell Transplantation in Retinal Disease: The New Frontier.Ophthalmology · 2016Review
- Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice.Scientific reports · 2016Article
- Biobanking of Human Retinas: The Next Big Leap for Eye Banks?Stem cells translational medicine · 2015Article
- Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors.Cell stem cell · 2015Article
- Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy.Stem cells (Dayton, Ohio) · 2015Article
- Current focus of stem cell application in retinal repair.World journal of stem cells · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Induced pluripotent stem cells (iPSc) are a scientific and medical frontier. Application of reprogrammed somatic cells for clinical trials is in its dawn period; advances in research with animal and human iPSc are paving the way for retinal therapies with the ongoing development of safe animal cell transplantation studies and characterization of patient- specific and disease-specific human iPSc. The retina is an optimal model for investigation of neural regeneration; amongst other advantageous attributes, it is the most accessible part of the CNS for surgery and outcome monitoring. A recent clinical trial showing a degree of visual restoration via a subretinal electronic prosthesis implies that even a severely degenerate retina may have the capacity for repair after cell replacement through potential plasticity of the visual system. Successful differentiation of neural retina from iPSc and the recent generation of an optic cup from human ESc invitro increase the feasibility of generating an expandable and clinically suitable source of cells for human clinical trials. In this review we shall present recent studies that have propelled the field forward and discuss challenges in utilizing iPS cell derived retinal cells as reliable models for clinical therapies and as a source for clinical cell transplantation treatment for patients suffering from genetic retinal disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.