ArticleInternational journal of physiology, pathophysiology and pharmacology2012
Serotonergic modulation of Neural activities in the entorhinal cortex.
Article in International journal of physiology, pathophysiology and pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
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- Electroacupuncture stimulation of auricular concha region improves loss of control over stress induced depression-like behavior by modulating 5-hydroxytryptamine 1A receptor.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- The role of hippocampal 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Serotonin receptors in epilepsy: Novel treatment targets?Epilepsia open · 2022Review
- Effect of ramosetron, a 5-HTThe journal of physiological sciences : JPS · 2022Article
- Neuropathology of the Brainstem to Mechanistically Understand and to Treat Alzheimer's Disease.Journal of clinical medicine · 2021Review
- Entorhinal cortex-based metabolic profiling of chronic restraint stress mice model of depression.Aging · 2020Article
- Regional tau pathology and loneliness in cognitively normal older adults.Translational psychiatry · 2018Article
- Diagnosis and Management of Neuropsychiatric Symptoms in Alzheimer's Disease.Current psychiatry reports · 2018Review
- Monoaminergic neuropathology in Alzheimer's disease.Progress in neurobiology · 2017Review
- Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology.Brain pathology (Zurich, Switzerland) · 2016Article
- Fluoxetine induces input-specific hippocampal dendritic spine remodeling along the septotemporal axis in adulthood and middle age.Hippocampus · 2015Article
- Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The entorhinal cortex (EC) is considered as the gate to control the flow of information into and out of the hippocampus. The EC is important for numerous physiological functions such as emotional control, learning and memory and pathological disorders including Alzheimer's disease, schizophrenia and temporal lobe epilepsy. Serotonin is a classical neurotransmitter which may modify these physiological functions and pathology of neurological diseases. The EC receives profuse serotonergic innervations from the raphe nuclei in the brainstem and expresses high density of serotonergic receptors including 5-HT(1A), 5-HT(1D), 5-HT(1E), 5-HT(2A), 5-HT(3) and 5-HT(6). The prominent innervation by serotonergic neurons and the dense expression of serotonergic receptors in the EC suggest that serotonin is a major modulator in this brain region. Serotonin exerts inhibitory effects in the EC. Serotonin hyperpolarizes entorhinal neurons and inhibits the excitatory synaptic transmission via activation of 5-HT(1A) receptors but facilitates GABA release via activation of 5-HT(2A) receptors. Both 5-HT(1A) and 5-HT(2A) receptors are required for serotonin-induced inhibition of epileptiform activity although 5-HT(3) receptors may be involved in serotonin-mediated inhibition of acetylcholine release in the EC. Furthermore, the functions of serotonin in the EC may be implicated in Parkinson's disease, Alzheimer's disease and depression. Thus, understanding the roles of serotonergic modulation in the EC is of major clinical importance. Here, I review recent findings concerning the effects of serotonin on neural circuitry activity in the EC.
Indexed as
Identifiers
23320133PMC3544218W59475270What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.