ArticleArchives of medical science : AMS2012
Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population.
Article in Archives of medical science : AMS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Genetic 135G/C polymorphism of RAD51 gene and risk of cancer: a meta-analysis of 28,956 cases and 28,372 controls.Familial cancer · 2014Pooled it
- Association of reduced XRCC2 expression with lymph node metastasis in breast cancer tissues.Familial cancer · 2014Pooled it
- The Arg188His polymorphism in the XRCC2 gene and the risk of cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.Diagnostic pathology · 2014Pooled it
- Pooled it
- Pooled it
- An association between the -41657 C/T polymorphism of X-ray repair cross-complementing 2 (XRCC2) gene and ovarian cancer.Medical oncology (Northwood, London, England) · 2014Trial
- XRCC2 gene polymorphisms and its protein are associated with colorectal cancer susceptibility in Chinese Han population.Medical oncology (Northwood, London, England) · 2014Trial
- The protective effects of the methylenetetrahydrofolate reductase rs1801131 variant among Saudi smokers.Saudi journal of biological sciences · 2021Article
- The most frequent PolishArchives of medical science : AMS · 2021Article
- The prevalence of waterpipe tobacco smoking among Polish youths.Archives of medical science : AMS · 2021Article
- Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis.International journal of genomics · 2019Review
- Determination ofDisease markers · 2019Article
- Association of Smoking and XPG, CYP1A1, OGG1, ERCC5, ERCC1, MMP2, and MMP9 Gene Polymorphisms with the early detection and occurrence of Laryngeal Squamous Carcinoma.Journal of Cancer · 2018Article
- Haplotype analysis of XRCC2 gene polymorphisms and association with increased risk of head and neck cancer.Scientific reports · 2017Article
- Interaction between MLL3 genetic polymorphisms, smoking, and alcohol drinking in laryngeal cancer: a case-control study.Cancer medicine · 2016Article
- Analysis ofBiomedical reports · 2016Article
- Polymorphisms in RAD51 and their relation with breast cancer in Saudi females.OncoTargets and therapy · 2016Article
- Single Nucleotide Polymorphisms (SNPs) of RAD51-G172T and XRCC2-41657C/T Homologous Recombination Repair Genes and the Risk of Triple- Negative Breast Cancer in Polish Women.Pathology oncology research : POR · 2015Article
- Association between RAD51 polymorphisms and susceptibility of head and neck cancer: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCigarette smoke and alcohol can generate reactive oxygen species, which may induce DNA double-strand breaks (DSBs), the most serious DNA lesion. In humans, DSBs are repaired mainly by non-homologous end joining and homologous recombination repair (HRR). Several polymorphisms in the DNA repair gene have been extensively studied in the association with various human cancers. In the present work we investigated the association between polymorphisms of two HRR genes, XRCC2 and RAD51, and tobacco- and alcohol-related larynx cancer in a Polish population. MATERIAL AND
methodsTwo polymorphisms of the XRCC2 gene, -41657C > T (rs718282) and 31479G > A (rs3218536), as well as one polymorphism of the RAD51 gene, -135G > C (rs1801320), were investigated by PCR-RFLP in 253 patients with larynx cancer and 253 age- and sex-matched non-cancer controls.
resultsAnalysis of the gene-smoking and -drinking interactions revealed a weak association between larynx cancer and the -41657C > T polymorphisms of the XRCC2 gene among the moderate alcohol drinkers. The C allele of the -135G > C polymorphism of RAD51 increased cancer risk in the smoker group. Increased risk was also found for heavy drinkers. Additionally, there were no significant differences between distributions of genotypes in subgroups assigned to different TNM stages and grades.
conclusionsThe results indicated that the -135G > C polymorphism of the RAD51 gene may be associated with smoking- and drinking-related larynx cancer in Poland.
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