Trial reportThe Journal of infectious diseases2013
Association of serum albumin concentration with mortality, morbidity, CD4 T-cell reconstitution among tanzanians initiating antiretroviral therapy.
Trial report in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Serum Albumin as a Prognostic Marker for Serious Non-AIDS Endpoints in the Strategic Timing of Antiretroviral Treatment (START) Study.The Journal of infectious diseases · 2018Trial
- Persistently Elevated C-Reactive Protein Level in the First Year of Antiretroviral Therapy, Despite Virologic Suppression, Is Associated With HIV Disease Progression in Resource-Constrained Settings.The Journal of infectious diseases · 2016Trial
- Concurrent Anemia and Elevated C-Reactive Protein Predicts HIV Clinical Treatment Failure, Including Tuberculosis, After Antiretroviral Therapy Initiation.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Trial
- Prediction Model for Detecting Active Pulmonary Tuberculosis in Patients With Head and Neck Cancer Prior to Concurrent Chemoradiotherapy.Journal of clinical medicine research · 2026Article
- Pulmonary complications in people living with HIV: a retrospective evaluation of the etiological spectrum and mortality-associated factors.BMC infectious diseases · 2026Article
- Predictors of opportunistic infections among people living with HIV: a prospective cohort study from a tertiary care setting in India.Scientific reports · 2026Article
- Hypoalbuminemia in HIV-infected patients: its determinants and correlation with CD4 count in Northern Uganda.AIDS research and therapy · 2025Article
- Associations between serum levels of liver function biomarkers and all-cause and cause-specific mortality: a prospective cohort study.BMC public health · 2024Article
- Prediction of the risk of cytopenia in hospitalized HIV/AIDS patients using machine learning methods based on electronic medical records.Frontiers in public health · 2023Article
- Profile of presentation of HIV-positive patients to an emergency department in Johannesburg, South Africa.Southern African journal of HIV medicine · 2021Article
- Multicenter Study of Controlling Nutritional Status (CONUT) Score as a Prognostic Factor in Patients With HIV-Related Renal Cell Carcinoma.Frontiers in immunology · 2021Article
- Trends and Adaptive Optimal Set Points of CD4AIDS research and treatment · 2020Article
- Neurocognitive impairment is worse in HIV/HCV-coinfected individuals with liver dysfunction.Journal of neurovirology · 2019Article
- Development and Evaluation of Physiologically Based Pharmacokinetic Drug-Disease Models for Predicting Rifampicin Exposure in Tuberculosis and Cirrhosis Populations.Pharmaceutics · 2019Article
- A routine blood test-associated predictive model and application for tuberculosis diagnosis: a retrospective cohort study from northwest China.The Journal of international medical research · 2019Article
- An Evaluation to Determine the Strongest CD4 Count Covariates during HIV Disease Progression in Women in South Africa.Infectious diseases and therapy · 2019Article
- Covariate random effects on the CD4 count variation during HIV disease progression in women.HIV/AIDS (Auckland, N.Z.) · 2019Article
- E-Selectin and markers of HIV disease severity, inflammation and coagulation in HIV-infected treatment-naïve individuals.African health sciences · 2018Article
- Serum Albumin Is Associated With Higher Inflammation and Carotid Atherosclerosis in Treated Human Immunodeficiency Virus Infection.Open forum infectious diseases · 2018Article
- All About the Albumin? Prognostic Capacity of Serum Albumin in Patients With Treated HIV Infection.The Journal of infectious diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundProspective studies of serum albumin concentration measurement as a low-cost predictor of human immunodeficiency virus (HIV) disease progression are needed for individuals initiating antiretroviral therapy (ART) in resource-limited settings.
methodsSerum albumin concentration was measured at ART initiation for 2145 adults in Tanzania who were enrolled in a trial examining the effect of multivitamins on HIV disease progression. Participants were prospectively followed for mortality, morbidity, and anthropometric outcomes at monthly visits (median follow-up duration, 21.2 months). Proportional hazard models were used to analyze mortality, morbidity, and nutritional outcomes, while generalized estimating equations were used to analyze CD4(+) T-cell counts.
resultsIndividuals with hypoalbuminemia (defined as a serum albumin concentration of <35 g/L) at ART initiation had a hazard of death that was 4.52 times (95% confidence interval, 3.37-6.07; P < .001) that of individuals with serum albumin concentrations of ≥ 35 g/L, after multivariate adjustment. Hypoalbuminemia was also independently associated with the incidence of pulmonary tuberculosis (P < .001), severe anemia (P < .001), wasting (P = .002), and >10% weight loss (P = .012). Secondary analyses suggested that serum albumin concentrations of <38 g/L were associated with increased mortality and incident pulmonary tuberculosis. There was no association between serum albumin concentration and changes in CD4(+) T-cell counts (P = .121).
conclusionsSerum albumin concentrations can identify adults initiating ART who are at high risk for mortality and selected morbidities. Future research is needed to identify and manage conditions that reduce the serum albumin concentration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.