Trial reportProceedings of the National Academy of Sciences of the United States of America2013
Coupling of functional connectivity and regional cerebral blood flow reveals a physiological basis for network hubs of the human brain.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 379 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
379 citing papers in PubMed, 3 syntheses or guidelines pooled it, 678 citations in OpenAlex.
- Lower brain glucose metabolism in normal ageing is predominantly frontal and temporal: A systematic review and pooled effect size and activation likelihood estimates meta-analyses.Human brain mapping · 2023Pooled it
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Building the bodily self-awareness: Evidence for the convergence between interoceptive and exteroceptive information in a multilevel kernel density analysis study.Human brain mapping · 2020Pooled it
- The relevance of rich club regions for functional outcome post-stroke is enhanced in women.Human brain mapping · 2023Trial
- Validation of cerebral blood flow connectivity as imaging prognostic biomarker on subcortical stroke.Journal of neurochemistry · 2021Trial
- Disturbed neurovascular coupling in type 2 diabetes mellitus patients: Evidence from a comprehensive fMRI analysis.NeuroImage. Clinical · 2019Trial
- Multimodal Brain Graph Analysis for Uncovering Path-Based Biomarkers in Schizophrenia: Integrating Static and Dynamic Approaches.Human brain mapping · 2026Article
- Unveiling Functional-Metabolic Synergy in the Healthy Brain: Multivariate Integration of Dynamic [Human brain mapping · 2026Article
- Neurovascular dysfunction in cerebral small vessel disease: impact on cognition and depression using arterial spin labeling and resting-state fMRI.Brain imaging and behavior · 2026Article
- Prefrontal Neurovascular Coupling Abnormalities Associated With Cognitive Performance in Multiple Sclerosis.CNS neuroscience & therapeutics · 2026Article
- Altered Neurovascular Coupling Dynamics During Dobutamine-Induced Acute Stress.Brain and behavior · 2026Article
- Distance-related functional connectivity alterations in first-episode, drug-naïve major depressive disorder: a resting-state fMRI study with atlas-based neurotransmitter correlates.BMC psychiatry · 2026Article
- Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression.Molecular psychiatry · 2026Article
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- Functional reorganisation of lingual gyrus mediates cognitive impairment in COPD: a multimodal neuroimaging study.ERJ open research · 2026Article
- Predicting individual incubation of opioid craving by whole-brain functional connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neurovascular Coupling Disruption and Glymphatic Dysfunction Are Associated With Visual Impairment in Pediatric Monocular Anisometropic Amblyopia.Investigative ophthalmology & visual science · 2026Article
- Altered neurovascular coupling in patients with human immunodeficiency virus-associated asymptomatic neurocognitive impairment: a multimodal magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2026Article
- Acute cannabidiol (CBD), tetrahydrocannabinol (THC) and their mixture (THC:CBD) exert differential effects on brain activity and blood flow in rats: A translational neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2026Article
- Energetic implications of fMRI-based nodal complex network metrics: a complex picture unfolds across diverse brain states.bioRxiv : the preprint server for biology · 2026Article
319 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Human brain functional networks contain a few densely connected hubs that play a vital role in transferring information across regions during resting and task states. However, the relationship of these functional hubs to measures of brain physiology, such as regional cerebral blood flow (rCBF), remains incompletely understood. Here, we used functional MRI data of blood-oxygenation-level-dependent and arterial-spin-labeling perfusion contrasts to investigate the relationship between functional connectivity strength (FCS) and rCBF during resting and an N-back working-memory task. During resting state, functional brain hubs with higher FCS were identified, primarily in the default-mode, insula, and visual regions. The FCS showed a striking spatial correlation with rCBF, and the correlation was stronger in the default-mode network (DMN; including medial frontal-parietal cortices) and executive control network (ECN; including lateral frontal-parietal cortices) compared with visual and sensorimotor networks. Moreover, the relationship was connection-distance dependent; i.e., rCBF correlated stronger with long-range hubs than short-range ones. It is notable that several DMN and ECN regions exhibited higher rCBF per unit connectivity strength (rCBF/FCS ratio); whereas, this index was lower in posterior visual areas. During the working-memory experiment, both FCS-rCBF coupling and rCBF/FCS ratio were modulated by task load in the ECN and/or DMN regions. Finally, task-induced changes of FCS and rCBF in the lateral-parietal lobe positively correlated with behavioral performance. Together, our results indicate a tight coupling between blood supply and brain functional topology during rest and its modulation in response to task demands, which may shed light on the physiological basis of human brain functional connectome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.