ArticleProceedings of the National Academy of Sciences of the United States of America2013
Minimization of thermodynamic costs in cancer cell invasion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
- Mapping cell-cell fusion at single-cell resolution.bioRxiv : the preprint server for biology · 2025Article
- The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria.Clinical & experimental metastasis · 2024Review
- Cellular Energy Cycle Mediates an Advection-Like Forward Cell Flow to Support Collective Invasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Collagen density regulates tip-stalk cell rearrangement during angiogenesis via cellular bioenergetics.APL bioengineering · 2024Article
- Metastatic cells exploit their stoichiometric niche in the network of cancer ecosystems.Science advances · 2023Article
- Moderate molecular recognitions on ZnONanoscale advances · 2022Article
- Morphodynamics facilitate cancer cells to navigate 3D extracellular matrix.Scientific reports · 2021Article
- Mechanoresponsive metabolism in cancer cell migration and metastasis.Cell metabolism · 2021Review
- Recent advances in understanding the role of metabolic heterogeneities in cell migration.Faculty reviews · 2021Review
- Metastasis: crosstalk between tissue mechanics and tumour cell plasticity.British journal of cancer · 2021Review
- Article
- Metabolic reprogramming dynamics in tumor spheroids: Insights from a multicellular, multiscale model.PLoS computational biology · 2019Article
- Energetic regulation of coordinated leader-follower dynamics during collective invasion of breast cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods.ACS biomaterials science & engineering · 2019Article
- Gastric cancer cells escape metabolic stress via the DLC3/MACC1 axis.Theranostics · 2019Article
- Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA-MB-231 breast cancer cell line.Oncology letters · 2018Article
- Microfabrication-Based Three-Dimensional (3-D) Extracellular Matrix Microenvironments for Cancer and Other Diseases.International journal of molecular sciences · 2018Review
- The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1.Molecular cancer · 2018Article
- Regulation of ATP utilization during metastatic cell migration by collagen architecture.Molecular biology of the cell · 2018Article
- An integrated method for cell isolation and migration on a chip.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastasis, the truly lethal aspect of cancer, occurs when metastatic cancer cells in a tumor break through the basement membrane and penetrate the extracellular matrix. We show that MDA-MB-231 metastatic breast cancer cells cooperatively invade a 3D collagen matrix while following a glucose gradient. The invasion front of the cells is a dynamic one, with different cells assuming the lead on a time scale of 70 h. The front cell leadership is dynamic presumably because of metabolic costs associated with a long-range strain field that precedes the invading cell front, which we have imaged using confocal imaging and marker beads imbedded in the collagen matrix. We suggest this could be a quantitative assay for an invasive phenotype tracking a glucose gradient and show that the invading cells act in a cooperative manner by exchanging leaders in the invading front.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.