ArticleInfection and immunity2013
Influenza-induced inflammation drives pneumococcal otitis media.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Dysregulation of immune response in otitis media.Expert reviews in molecular medicine · 2021Pooled it
- Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations.The Journal of allergy and clinical immunology · 2014Trial
- Estimating the Range and Duration of Post-influenza Symptoms, Conditions, and Diseases.Open forum infectious diseases · 2026Article
- Disease burden associated with influenza activity at the population level.Epidemiology and infection · 2026Article
- Trends in otitis media burden among BRICS from 1990 to 2023 and projections to 2040: an age-period-cohort analysis based on the 2023 global burden of disease study.Italian journal of pediatrics · 2026Article
- A Trivalent Live Vaccine Elicits Cross-Species Protection Against Acute Otitis Media in a Murine Model.Vaccines · 2024Article
- An infant mouse model of influenza-driven nontypeableInfection and immunity · 2024Article
- Evidence for vagal sensory neural involvement in influenza pathogenesis and disease.PLoS pathogens · 2024Article
- A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants.eLife · 2021Article
- Effect of aerosolized bacterial lysate on development of naturally occurring respiratory disease in beef calves.Journal of veterinary internal medicine · 2021Article
- Innate Immunity in the Middle Ear Mucosa.Frontiers in cellular and infection microbiology · 2021Review
- Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection.Frontiers in cellular and infection microbiology · 2021Article
- High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier.eLife · 2020Article
- Double-Edged Role of Interleukin 17A in Streptococcus pneumoniae Pathogenesis During Influenza Virus Coinfection.The Journal of infectious diseases · 2019Article
- Back to the Future: Lessons Learned From the 1918 Influenza Pandemic.Frontiers in cellular and infection microbiology · 2018Review
- Article
- Pneumococcal Neuraminidase A (NanA) Promotes Biofilm Formation and Synergizes with Influenza A Virus in Nasal Colonization and Middle Ear Infection.Infection and immunity · 2017Article
- Panel 4: Report of the Microbiology Panel.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2017Review
- Influenza A Virus Infection Predisposes Hosts to Secondary Infection with Different Streptococcus pneumoniae Serotypes with Similar Outcome but Serotype-Specific Manifestation.Infection and immunity · 2016Article
- Free Sialic Acid Acts as a Signal That Promotes Streptococcus pneumoniae Invasion of Nasal Tissue and Nonhematogenous Invasion of the Central Nervous System.Infection and immunity · 2016Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influenza A virus (IAV) predisposes individuals to secondary infections with the bacterium Streptococcus pneumoniae (the pneumococcus). Infections may manifest as pneumonia, sepsis, meningitis, or otitis media (OM). It remains controversial as to whether secondary pneumococcal disease is due to the induction of an aberrant immune response or IAV-induced immunosuppression. Moreover, as the majority of studies have been performed in the context of pneumococcal pneumonia, it remains unclear how far these findings can be extrapolated to other pneumococcal disease phenotypes such as OM. Here, we used an infant mouse model, human middle ear epithelial cells, and a series of reverse-engineered influenza viruses to investigate how IAV promotes bacterial OM. Our data suggest that the influenza virus HA facilitates disease by inducing a proinflammatory response in the middle ear cavity in a replication-dependent manner. Importantly, our findings suggest that it is the inflammatory response to IAV infection that mediates pneumococcal replication. This study thus provides the first evidence that inflammation drives pneumococcal replication in the middle ear cavity, which may have important implications for the treatment of pneumococcal OM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.