ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2013
Inhibition of DNA synthesis facilitates expansion of low-complexity repeats: is strand slippage stimulated by transient local depletion of specific dNTPs?
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability.The Journal of biological chemistry · 2020Review
- Association of intron microsatellite status and exon mutational profiles of TP53 in human colorectal cancer.Experimental and therapeutic medicine · 2019Article
- Mutagenic potential of hypoxanthine in live human cells.Mutation research · 2017Article
- Potentiation of hydrogen peroxide toxicity: From catalase inhibition to stable DNA-iron complexes.Mutation research. Reviews in mutation research · 2017Review
- Review
- FANCJ is essential to maintain microsatellite structure genome-wide during replication stress.Nucleic acids research · 2016Article
- Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus.Human molecular genetics · 2015Article
- BLM helicase facilitates telomere replication during leading strand synthesis of telomeres.The Journal of cell biology · 2015Article
- Expansion of CAG repeats in Escherichia coli is controlled by single-strand DNA exonucleases of both polarities.Genetics · 2014Article
- Deoxyribonucleotides as genetic and metabolic regulators.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Review
- Role of DNA polymerase κ in the maintenance of genomic stability.Molecular & cellular oncology · 2014Review
- Hypothesis: local dNTP depletion as the cause of microsatellite repeat instability during replication (comment on DOI 10.1002/bies.201200128).BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
Corrections and comments
- Commented on by
Authors and funding
1 author.
Funding
Abstract
Simple DNA repeats (trinucleotide repeats, micro- and minisatellites) are prone to expansion/contraction via formation of secondary structures during DNA synthesis. Such structures both inhibit replication forks and create opportunities for template-primer slippage, making these repeats unstable. Certain aspects of simple repeat instability, however, suggest additional mechanisms of replication inhibition dependent on the primary DNA sequence, rather than on secondary structure formation. I argue that expanded simple repeats, due to their lower DNA complexity, should transiently inhibit DNA synthesis by locally depleting specific DNA precursors. Such transient inhibition would promote formation of secondary structures and would stabilize these structures, facilitating strand slippage. Thus, replication problems at simple repeats could be explained by potentiated toxicity, where the secondary structure-driven repeat instability is enhanced by DNA polymerase stalling at the low complexity template DNA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.