ArticleInternational journal of cancer2013
Risk of advanced gastric precancerous lesions in Helicobacter pylori infected subjects is influenced by ABO blood group and cagA status.
Article in International journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Association between ABO blood groups and hematological myeloid neoplasms in adolescents and adults.Frontiers in medicine · 2024Article
- Article
- Human ABO Blood Groups and Their Associations with Different Diseases.BioMed research international · 2021Review
- Article
- Overview of Current Concepts in Gastric Intestinal Metaplasia and Gastric Cancer.Gastroenterology & hepatology · 2018Article
- Receiver operating characteristic analysis of prediction for gastric cancer development using serum pepsinogen and Helicobacter pylori antibody tests.BMC cancer · 2017Article
- Blood type biochemistry and human disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- The prognostic value of ABO blood group in cancer patients.Blood transfusion = Trasfusione del sangue · 2016Review
- Trans-species polymorphism in humans and the great apes is generally maintained by balancing selection that modulates the host immune response.Human genomics · 2015Review
- Blood Groups in Infection and Host Susceptibility.Clinical microbiology reviews · 2015Review
- Effect ofExperimental and therapeutic medicine · 2015Article
- ABO blood types and cancer risk--a cohort study of 339,432 subjects in Taiwan.Cancer epidemiology · 2015Article
- Hemostasis, cancer, and ABO blood group: the most recent evidence of association.Journal of thrombosis and thrombolysis · 2014Review
- Possible role of ABO system in age-related diseases and longevity: a narrative review.Immunity & ageing : I & A · 2014Review
- Gastric cancer-molecular and clinical dimensions.Nature reviews. Clinical oncology · 2013Review
- Beyond immunohaematology: the role of the ABO blood group in human diseases.Blood transfusion = Trasfusione del sangue · 2013Review
- Review
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Authors and funding
8 authors at 6 institutions in 5 countries.
Funding
Abstract
A higher incidence of stomach cancer in ABO blood type A individuals than in those with blood type O has been known for a long time. We studied this association in relation to Helicobacter pylori (Hp) of different cagA status. For our study, we used baseline gastric histopathology data and DNAs from frozen gastric biopsies of 2,077 subjects enrolled in a chemoprevention trial for gastric precancerous lesions in Venezuela. We analyzed six single nucleotide polymorphisms in the ABO gene, and we assessed the presence of the Hp cagA gene. Odds ratios (ORs) for risk of advanced precancerous gastric lesions were calculated using individuals with normal gastric epithelium or non-atrophic gastritis as a reference. Among individuals carrying a cagA negative Hp infection or no Hp infection, those with blood type A had a lower risk of intestinal metaplasia (IM) and dysplasia than those with blood type O (OR=0.60; 95% CI 0.38-0.94). In carriers of cagA positive Hp strains, individuals with blood type A had a higher risk of IM or dysplasia than those with blood type O (OR=1.42, 95% CI 1.09-1.86) and a higher risk if compared to subjects carrying cagA negative strain and non-A blood group (OR=3.82, 95% CI=2.80-5.20). The interaction between Hp cagA status and blood type was statistically significant (p=0.0006). We showed that SNPs in the ABO gene, predictive of ABO blood groups, are associated with risk of advanced precancerous gastric lesions in individuals infected with Hp, but the assessment of the risk is strictly dependent on cagA status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.