ArticleThe International journal of developmental biology2012
Roles of EphB3/ephrin-B1 in feather morphogenesis.
Article in The International journal of developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Genetic Differences in Purple Finch (Ecology and evolution · 2026Article
- Article
- Medulla-free barb rami highlight the morphological diversity of early feathers.Zoological research · 2025Article
- Genome Assembly and Evolutionary Analysis of the Mandarin Duck Aix galericulata Reveal Strong Genome Conservation among Ducks.Genome biology and evolution · 2022Article
- Article
- Transmission electron microscopic and immunohistochemical observations of resting follicles of feathers in chicken show massive cell degeneration.Anatomical science international · 2018Article
- Genetic analyses in Lake Malawi cichlids identify new roles for Fgf signaling in scale shape variation.Communications biology · 2018Article
- Genomic determinants of epidermal appendage patterning and structure in domestic birds.Developmental biology · 2017Article
- Pigeonetics takes flight: Evolution, development, and genetics of intraspecific variation.Developmental biology · 2017Review
- Ephrin-B/EphB Signaling Is Required for Normal Innervation of Lingual Gustatory Papillae.Developmental neuroscience · 2016Article
- Transcriptomic analyses of regenerating adult feathers in chicken.BMC genomics · 2015Article
- Convergent Evolution of Head Crests in Two Domesticated Columbids Is Associated with Different Missense Mutations in EphB2.Molecular biology and evolution · 2015Article
- Development, regeneration, and evolution of feathers.Annual review of animal biosciences · 2015Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The ephrin receptor (Eph) tyrosine kinases and their ephrin ligands are involved in morphogenesis during organ formation. We studied their role in feather morphogenesis, focusing on ephrin-B1 and its receptor EphB3. Early in feather development, ephrin-B1 mRNA and protein were found to be expressed in the dermal condensation, but not in the inter-bud mesenchyme. Later, in feather buds, expression was found in both the epithelium and mesenchyme. In the feather follicle, ephrin-B1 protein expression was found to be enriched in the feather filament epithelium and in the marginal plate which sets the boundary between the barb ridges. EphB3 mRNA was also expressed in epithelia. In the feather bud, its expression was restricted to the posterior bud. In the follicle, its expression formed a circle at the bud base which may set the boundary between bud and inter-bud domains. Perturbation with ephrin-B1/Fc altered feather primordia segregation and feather bud elongation. Analyses revealed that ephrin-B1/Fc caused three types of changes: blurred placode boundaries with loose dermal condensations, incomplete follicle invagination with less compact dermal papillae, and aberrant barb ridge patterning in feather filament morphogenesis. Thus, while ephrin-B1 suppression does not inhibit the initial emergence of a new epithelial domain, Eph/ephrin-B1 interaction is required for its proper completion. Consequently, we propose that interaction between ephrin-B1 and its receptor is involved in boundary stabilization during feather morphogenesis.
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