ArticleNeuroscience bulletin2013
The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala.
Article in Neuroscience bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Anxiety and Depression Traits Are Moderated by a Sex-Dependent Genetic Interaction Between 5-HTTLPR and BDNF.Brain sciences · 2026Article
- Lifestyle, Early-life, and Genetic Health Risk Factors Underlying the Brain Age Gap: A Mega-Analysis Across 3,934 Individuals from the ENIGMA MDD Consortium.bioRxiv : the preprint server for biology · 2025Article
- Aberrant resting-state co-activation network dynamics in major depressive disorder.Translational psychiatry · 2024Article
- Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms.Scientific reports · 2021Article
- An integrative analysis of 5HTT-mediated mechanism of hyperactivity to non-threatening voices.Communications biology · 2020Article
- CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research.Molecular psychiatry · 2020Review
- Reduced default mode network functional connectivity in patients with recurrent major depressive disorder.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Social Isolation During Adolescence Induces Anxiety Behaviors and Enhances Firing Activity in BLA Pyramidal Neurons via mGluR5 Upregulation.Molecular neurobiology · 2018Article
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Associations Between PPP1R1B Gene Polymorphisms and Anxiety Levels in the Chinese Population.Neuroscience bulletin · 2017Article
- The analysis of anxiety and mood in healthy late-reproductive-stage women with regard to hormonal and genetic factors.Archives of women's mental health · 2016Article
- Anxiogenic CO2 stimulus elicits exacerbated hot flash-like responses in a rat menopause model and hot flashes in postmenopausal women.Menopause (New York, N.Y.) · 2016Article
- COMT Val158Met polymorphism influences the susceptibility to framing in decision-making: OFC-amygdala functional connectivity as a mediator.Human brain mapping · 2016Article
- Dopamine-System Genes and Cultural Acquisition: The Norm Sensitivity Hypothesis.Current opinion in psychology · 2016Article
- RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory.Human brain mapping · 2015Article
- Altered inhibition-related frontolimbic connectivity in obsessive-compulsive disorder.Human brain mapping · 2015Article
- Post-training activation of Rac1 in the basolateral amygdala is required for the formation of both short-term and long-term auditory fear memory.Frontiers in molecular neuroscience · 2015Article
- Genetic variations in the serotonergic system contribute to amygdala volume in humans.Frontiers in neuroanatomy · 2015Article
- Perceived Parenting Mediates Serotonin Transporter Gene (5-HTTLPR) and Neural System Function during Facial Recognition: A Pilot Study.PloS one · 2015Article
- Altered brain network modules induce helplessness in major depressive disorder.Journal of affective disorders · 2014Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in generelated studies and their potential clinical applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.