ArticleIntegrative biology : quantitative biosciences from nano to macro2013
Functional interplay between the cell cycle and cell phenotypes.
Article in Integrative biology : quantitative biosciences from nano to macro, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
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- Stain-Free Approach to Determine and Monitor Cell Heath Using Supervised and Unsupervised Image-Based Deep Learning.Journal of pharmaceutical sciences · 2024Article
- Self-supervised classification of subcellular morphometric phenotypes reveals extracellular matrix-specific morphological responses.Scientific reports · 2022Article
- Morphometry and Modeling of Label-Free Human Melanocytes and Melanoma Cells.Cell biochemistry and biophysics · 2021Article
- Single-cell morphology encodes metastatic potential.Science advances · 2020Article
- Xeroderma Pigmentosum Group D (XPD) Inhibits the Proliferation Cycle of Vascular Smooth Muscle Cell (VSMC) by Activating Glycogen Synthase Kinase 3β (GSK3β).Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Biophysical and biomolecular determination of cellular age in humans.Nature biomedical engineering · 2017Article
- TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse Testis.Biology of reproduction · 2016Article
- MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents.Oncogene · 2016Article
- Machine learning based methodology to identify cell shape phenotypes associated with microenvironmental cues.Biomaterials · 2016Article
- PAC1R agonist maxadilan enhances hADSC viability and neural differentiation potential.Journal of cellular and molecular medicine · 2016Article
- Article
- Evolution of cellular morpho-phenotypes in cancer metastasis.Scientific reports · 2015Article
- Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions.Oncotarget · 2015Article
- SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors.Molecular biology of the cell · 2015Article
- Cytoskeletal tension induces the polarized architecture of the nucleus.Biomaterials · 2015Article
- Transcriptional and translational heterogeneity among neonatal mouse spermatogonia.Biology of reproduction · 2015Article
- Potential Gene Interactions in the Cell Cycles of Gametes, Zygotes, Embryonic Stem Cells and the Development of Cancer.Frontiers in oncology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Cell cycle distribution of adherent cells is typically assessed using flow cytometry, which precludes the measurements of many cell properties and their cycle phase in the same environment. Here we develop and validate a microscopy system to quantitatively analyze the cell-cycle phase of thousands of adherent cells and their associated cell properties simultaneously. This assay demonstrates that population-averaged cell phenotypes can be written as a linear combination of cell-cycle fractions and phase-dependent phenotypes. By perturbing the cell cycle through inhibition of cell-cycle regulators or changing nuclear morphology by depletion of structural proteins, our results reveal that cell cycle regulators and structural proteins can significantly interfere with each other's prima facie functions. This study introduces a high-throughput method to simultaneously measure the cell cycle and phenotypes at single-cell resolution, which reveals a complex functional interplay between the cell cycle and cell phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.