ArticleMolecular therapy : the journal of the American Society of Gene Therapy2013
Muscle-derived stem cell sheets support pump function and prevent cardiac arrhythmias in a model of chronic myocardial infarction.
Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Bioprinted Notch ligand to function as stem cell niche improves muscle regeneration in dystrophic muscle.International journal of bioprinting · 2023Article
- Measurement of the Adipose Stem Cells Cell Sheets Transmittance.Bioengineering (Basel, Switzerland) · 2021Article
- Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function.Molecular therapy. Methods & clinical development · 2020Article
- Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction.Stem cell research & therapy · 2020Review
- Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy.Macromolecular bioscience · 2016Article
- Stem cell therapy: a promising biological strategy for tendon-bone healing after anterior cruciate ligament reconstruction.Cell proliferation · 2016Review
- Application of the cell sheet technique in tissue engineering.Biomedical reports · 2015Article
- Combined biophysical and soluble factor modulation induces cardiomyocyte differentiation from human muscle derived stem cells.Scientific reports · 2014Article
- Concise review: skeletal muscle stem cells and cardiac lineage: potential for heart repair.Stem cells translational medicine · 2014Review
- Gene expression profiles in engineered cardiac tissues respond to mechanical loading and inhibition of tyrosine kinases.Physiological reports · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Direct intracardiac cell injection for heart repair is hindered by numerous limitations including: cell death, poor spreading of the injected cells, arrhythmia, needle injury, etc. Tissue-engineered cell sheet implantation has the potential to overcome some of these limitations. We evaluated whether the transplantation of a muscle-derived stem cell (MDSC) sheet could improve the regenerative capacity of MDSCs in a chronic model of myocardial infarction. MDSC sheet-implanted mice displayed a reduction in left ventricle (LV) dilation and sustained LV contraction compared with the other groups. The MDSC sheet formed aligned myotubes and produced a significant increase in capillary density and a reduction of myocardial fibrosis compared with the other groups. Hearts transplanted with the MDSC sheets did not display any significant arrhythmias and the donor MDSC survival rate was higher than the direct myocardial MDSC injection group. MDSC sheet implantation yielded better functional recovery of chronic infarcted myocardium without any significant arrhythmic events compared with direct MDSC injection, suggesting this cell sheet delivery system could significantly improve the myocardial regenerative potential of the MDSCs.
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Registered trials
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