ArticleMolecular and cellular biology2013
Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe.
Article in Molecular and cellular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 32 citations in OpenAlex.
- Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development.Genes & development · 2026Article
- The Lsm1-7 complex couples 3'-end protection to histone H4 acetylation to maintain mRNA homeostasis in Fusarium graminearum.Nucleic acids research · 2026Article
- Roles of P-body factors inbioRxiv : the preprint server for biology · 2025Article
- Roles of P-body factors in Candida albicans filamentation and stress response.PLoS genetics · 2025Article
- Proteomic composition of eukaryotic and bacterial RNA decay condensates suggests convergent evolution.Current opinion in microbiology · 2024Review
- Eukaryotic mRNA Decapping Activation.Frontiers in genetics · 2022Review
- The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast.International journal of molecular sciences · 2021Article
- The fission yeast Pin1 peptidyl-prolyl isomerase promotes dissociation of Sty1 MAPK from RNA polymerase II and recruits Ssu72 phosphatase to facilitate oxidative stress induced transcription.Nucleic acids research · 2021Article
- Fission Yeast Puf2, a Pumilio and FBF Family RNA-Binding Protein, Links Stress Granules to Processing Bodies.Molecular and cellular biology · 2020Article
- Dcp2: an mRNA decapping enzyme that adopts many different shapes and forms.Current opinion in structural biology · 2019Review
- Control of mRNA decapping by autoinhibition.Nucleic acids research · 2018Article
- P-Bodies: Composition, Properties, and Functions.Biochemistry · 2018Review
- Application of aRNA (New York, N.Y.) · 2018Article
- A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping.Nucleic acids research · 2017Article
- Involvement of fission yeast Pdc2 in RNA degradation and P-body function.RNA (New York, N.Y.) · 2017Article
- The Aspergillus nidulans Pbp1 homolog is required for normal sexual development and secondary metabolism.Fungal genetics and biology : FG & B · 2017Article
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- In vitro reconstitution of a cellular phase-transition process that involves the mRNA decapping machinery.Angewandte Chemie (International ed. in English) · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
P bodies are cytoplasmic RNA granules containing the Dcp1-Dcp2 decapping enzymes where mRNA decay can occur. Here, we describe the characterization of P bodies in the fission yeast Schizosaccharomyces pombe. Most information on the property and function of P bodies stems from studies in the distantly related budding yeast Saccharomyces cerevisiae, and Edc3 was identified as a scaffold protein required for P-body assembly. However, we found that, unlike in S. cerevisiae, fission yeast Edc3 was dispensable for P-body formation. Pdc1, a novel partner of the fission yeast decapping enzyme, with a limited similarity to plant Edc4/Varicose that is required for the assembly of P bodies, was identified (tandem affinity purification-matrix-assisted laser desorption ionization tandem mass spectrometry [TAP-MALDI MS/MS]). Pdc1 interacts with Dcp2 through its C terminus and contains a coiled-coil region for self-interaction to mediate P-body formation. In line with the model that Pdc1 cross-bridges different proteins, additional interactions can be demonstrated with components such as Edc3 and Ste13. Although Pdc1 is not required for the interaction between Dcp1 and Dcp2, our data suggest that Pdc1 acts as a functional homologue of Edc4, a third component of the decapping enzymes that is thought to be absent from fungi. Together, these results highlight the diverse P-body protein compositions between different species and might help to provide insight into their evolutionary paths.
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