Evidence map›Paper›PMID 23319006›Full record

Trial reportMolecular psychiatry2014

MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy.

A Reif, J Richter, B Straube, M Höfler, U Lueken, A T Gloster, H Weber, K Domschke, L Fehm, A Ströhle and 15 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

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  19. Genetics of Anxiety Disorders.Current psychiatry reports · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 11 institutions in 1 country.

A ReifPsychiatric Neurobiology and Bipolar Disorder Program, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
J RichterDepartment of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.
B StraubeDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
M HöflerDepartment of Psychology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
U LuekenDepartment of Psychology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
A T GlosterDepartment of Psychology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
H WeberPsychiatric Neurobiology and Bipolar Disorder Program, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
K Domschke1] Psychiatric Neurobiology and Bipolar Disorder Program, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany [2] Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.
L FehmDepartment of Psychology, Humboldt-University Berlin, Berlin, Germany.
A StröhleDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
A JansenDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
A GerlachInstitute of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.
M PykaDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
I ReinhardtDepartment of Psychiatry and Psychotherapy, RWTH- Aachen, Aachen, Germany.
C Konrad1] Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany [2] Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.
A WittmannDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
B PfleidererDepartment of Clinical Radiology, University of Münster, Münster, Germany.
G W AlpersChair of Clinical and Biological Psychology, School of Social Sciences and Otto-Selz-Institute, University of Mannheim, Mannheim, Germany.
P PauliDepartment of Psychology, University of Würzburg, Würzburg, Germany.
T LangChristoph-Dornier-Stiftung for Clinical Psychology, Institute Bremen, Bremen, Germany.
V AroltDepartment of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.
H-U WittchenDepartment of Psychology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
A HammDepartment of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.
T KircherDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
J DeckertPsychiatric Neurobiology and Bipolar Disorder Program, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
Philipps University of Marburg · DETU Dresden · DEUniversity of Würzburg · DECharité - Universitätsmedizin Berlin · DEUniversität Greifswald · DEUniversity of Münster · DEDornier (Germany) · DEHumboldt-Universität zu Berlin · DERWTH Aachen University · DEUniversity of Cologne · DEUniversity of Mannheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Panic disorder with agoraphobia (PD/AG) is a prevalent mental disorder featuring a substantial complex genetic component. At present, only a few established risk genes exist. Among these, the gene encoding monoamine oxidase A (MAOA) is noteworthy given that genetic variation has been demonstrated to influence gene expression and monoamine levels. Long alleles of the MAOA-uVNTR promoter polymorphism are associated with PD/AG and correspond with increased enzyme activity. Here, we have thus investigated the impact of MAOA-uVNTR on therapy response, behavioral avoidance and brain activity in fear conditioning in a large controlled and randomized multicenter study on cognitive behavioral therapy (CBT) in PD/AG. The study consisted of 369 PD/AG patients, and genetic information was available for 283 patients. Carriers of the risk allele had significantly worse outcome as measured by the Hamilton Anxiety scale (46% responders vs 67%, P=0.017). This was accompanied by elevated heart rate and increased fear during an anxiety-provoking situation, that is, the behavioral avoidance task. All but one panic attack that happened during this task occurred in risk allele carriers and, furthermore, risk allele carriers did not habituate to the situation during repetitive exposure. Finally, functional neuroimaging during a classical fear conditioning paradigm evidenced that the protective allele is associated with increased activation of the anterior cingulate cortex upon presentation of the CS+ during acquisition of fear. Further differentiation between high- and low-risk subjects after treatment was observed in the inferior parietal lobes, suggesting differential brain activation patterns upon CBT. Taken together, we established that a genetic risk factor for PD/AG is associated with worse response to CBT and identify potential underlying neural mechanisms. These findings might govern how psychotherapy can include genetic information to tailor individualized treatment approaches.

Indexed as

AgoraphobiaBrainCognitive Behavioral TherapyConditioning, ClassicalElectrocardiographyFemaleFollow-Up StudiesGene FrequencyGenotypeHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMinisatellite RepeatsMonoamine OxidaseOxygenMonoamine Oxidasemonoamine oxidase A, humanOxygen

Identifiers

PMID23319006
OpenAlexW2002972684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.