ArticleJournal of assisted reproduction and genetics2013
Balanced chromosomal translocations in men: relationships among semen parameters, chromatin integrity, sperm meiotic segregation and aneuploidy.
Article in Journal of assisted reproduction and genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Rare Double Reciprocal Translocations in a Man with Reproductive Success and Recurrent Pregnancy Loss.Balkan journal of medical genetics : BJMG · 2026Article
- Evaluating the Impact of Hyaluronic Acid on Sperm Quality Before and After Cryopreservation in A Moroccan Cohort: A Pilot Study.Journal of family & reproductive health · 2025Article
- Asthenozoospermia in a patient with reciprocal translocation t(12;15): A case report.Urology case reports · 2025Article
- Male gamete copies to characterize genome inheritance and generate progenies.Scientific reports · 2025Article
- The intricate "ART" of ICSI.Journal of assisted reproduction and genetics · 2025Review
- Sperm Meiotic Segregation Analysis of Reciprocal Translocations Carriers: We Have Bigger FISH to Fry.International journal of molecular sciences · 2023Review
- A case of complex balanced chromosomal translocations associated with adverse pregnancy outcomes.Molecular cytogenetics · 2022Article
- FISH analysis of numerical chromosomal abnormalities in the sperm of robertsonian translocation der(13; 14)(q10;q10) carriers.Frontiers in genetics · 2022Article
- Chronic Exposure to Cadmium Induces Differential Methylation in Mice Spermatozoa.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Y chromosome microdeletion and cytogenetic findings in male infertility: A cross-sectional descriptive study.International journal of reproductive biomedicine · 2021Article
- How much, if anything, do we know about sperm chromosomes of Robertsonian translocation carriers?Cellular and molecular life sciences : CMLS · 2020Review
- Male Infertility in Robertsonian Translocation: A Case Report.The American journal of case reports · 2020Article
- SYCP2 Translocation-Mediated Dysregulation and Frameshift Variants Cause Human Male Infertility.American journal of human genetics · 2020Article
- Recent advances and future opportunities to diagnose male infertility.Current sexual health reports · 2019Article
- Cancer Treatment-Related Infertility: A Critical Review of the Evidence.JNCI cancer spectrum · 2019Review
- Non-Robertsonian translocations involving chromosomes 13, 14, or 15 in male infertility: 28 cases and a review of the literature.Medicine · 2019Article
- The effect of Robertsonian translocations on the intranuclear positioning of NORs (nucleolar organizing regions) in human sperm cells.Scientific reports · 2019Article
- Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations.Journal of assisted reproduction and genetics · 2019Article
- Clinical Features of Infertile Men Carrying a Chromosome 9 Translocation.Open medicine (Warsaw, Poland) · 2019Article
- Genetic evaluation of patients with non-syndromic male infertility.Journal of assisted reproduction and genetics · 2018Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyse relationships between semen parameters, sperm chromatin integrity and frequencies of chromosomally unbalanced, disomic and diploid sperm in 13 Robertsonian and 37 reciprocal translocation carriers and to compare the results with data from 10 control donors.
methodsConventional semen analysis, Sperm Chromatin Structure Assay and FISH with probes for chromosomes involved in the individual translocations and for chromosomes X, Y, 7, 8, 13, 18 and 21.
resultsNormal semen parameters were found in 30.8 % of Robertsonian and 59.5 % of reciprocal translocation carriers. The rates of unbalanced sperm were 12.0 % in Robertsonian and 55.1 % in reciprocal translocation carriers with no difference between normospermic patients and those showing altered semen parameters. Significantly increased frequencies of spermatozoa showing defects in chromatin integrity and condensation, aneuploidy for chromosomes not involved in a translocation and diploidy were detected in translocation carriers with abnormal semen parameters. Normospermic reciprocal translocation carriers showed an increase in chromosome 13 disomy compared to the control group. There was no relationship between gametic and somatic aneuploidy in 12 translocation carriers studied by FISH on sperm and lymphocytes. The frequency of motile sperm was negatively correlated with the frequency of sperm showing disomy, diploidy and defective chromatin condensation.
conclusionsAbnormal semen parameters can serve as indicators of an additional risk of forming spermatozoa with defective chromatin and aneuploidy in translocation carriers.
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