ArticleThe Journal of physiology2013
Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 32 citations in OpenAlex.
- The HCN4 channel modulates external tufted cell burst firing.Journal of neurophysiology · 2026Article
- Glomerulus-Specific Inhomogeneity of the Basal Activity Map in the Olfactory Bulb.International journal of molecular sciences · 2026Article
- Article
- The impact of HCN4 channels on CNS brain networks as a new target in pain development.Frontiers in network physiology · 2023Article
- Olfactory marker protein interacts with adenosine nucleotide derivatives.Biochemistry and biophysics reports · 2021Article
- Expression of the pacemaker channel HCN4 in excitatory interneurons in the dorsal horn of the murine spinal cord.Molecular brain · 2020Article
- Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons.Nature communications · 2020Article
- A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision.Frontiers in cellular neuroscience · 2020Review
- Using a Multiplex Nucleic AcidFrontiers in molecular neuroscience · 2019Article
- Second messenger molecules have a limited spread in olfactory cilia.The Journal of general physiology · 2018Article
- HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node.The Journal of physiology · 2018Article
- Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via βFrontiers in cellular neuroscience · 2017Article
- The Ca2+-activated Cl- channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons.The Journal of general physiology · 2016Article
- Spontaneously active NaV1.5 sodium channels may underlie odor sensitivity.Journal of neurophysiology · 2016Article
- Shh-proteoglycan interactions regulate maturation of olfactory glomerular circuitry.Developmental neurobiology · 2014Article
- NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons.Journal of neurophysiology · 2014Article
- Spontaneous and sensory-evoked activity in mouse olfactory sensory neurons with defined odorant receptors.Journal of neurophysiology · 2013Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory receptor neurons (ORNs), which undergo lifelong neurogenesis, have been studied extensively to understand how neurons form precise topographical networks. Neural projections from ORNs are principally guided by the genetic code, which directs projections from ORNs that express a specific odorant receptor to the corresponding glomerulus in the olfactory bulb. In addition, ORNs utilise spontaneous firing activity to establish and maintain the neural map. However, neither the process of generating this spontaneous activity nor its role as a guidance cue in the olfactory bulb is clearly understood. Utilising extracellular unit-recordings in mouse olfactory epithelium slices, we demonstrated that the hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels in the somas of ORNs depolarise their membranes and boost their spontaneous firing rates by sensing basal cAMP levels; the odorant-sensitive cyclic nucleotide-gated (CNG) channels in cilia do not. The basal cAMP levels were maintained via the standing activation of β-adrenergic receptors. Using a Tet-off system to over-express HCN4 channels resulted in the enhancement of spontaneous ORN activity and dramatically reduced both the size and number of glomeruli in the olfactory bulb. This phenotype was rescued by the administration of doxycycline. These findings suggest that cAMP plays different roles in cilia and soma and that basal cAMP levels in the soma are directly converted via HCN channels into a spontaneous firing frequency that acts as an intrinsic guidance cue for the formation of olfactory networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.