ArticleThe Journal of physiology2013
Tonic inhibition sets the state of excitability in olfactory bulb granule cells.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 33 citations in OpenAlex.
- Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration.Frontiers in molecular neuroscience · 2026Review
- Sex and Age-Dependent Olfactory Memory Dysfunction in ADHD Model Mice.Life (Basel, Switzerland) · 2023Article
- Long-range GABAergic projections contribute to cortical feedback control of sensory processing.Nature communications · 2022Article
- Connectivity and dynamics in the olfactory bulb.PLoS computational biology · 2022Article
- Review
- Dendritic integration in olfactory bulb granule cells upon simultaneous multispine activation: Low thresholds for nonlocal spiking activity.PLoS biology · 2020Article
- GABAergic modulation of olfactomotor transmission in lampreys.PLoS biology · 2018Article
- Parallel odor processing by mitral and middle tufted cells in the olfactory bulb.Scientific reports · 2018Article
- Short-Term Plasticity at Olfactory Cortex to Granule Cell Synapses Requires CaFrontiers in cellular neuroscience · 2018Article
- Inhibitory circuits of the mammalian main olfactory bulb.Journal of neurophysiology · 2017Review
- Two-Photon NaFrontiers in cellular neuroscience · 2017Article
- Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb.Scientific reports · 2016Article
- Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Sniff-Like Patterned Input Results in Long-Term Plasticity at the Rat Olfactory Bulb Mitral and Tufted Cell to Granule Cell Synapse.Neural plasticity · 2016Article
- Glomerular and Mitral-Granule Cell Microcircuits Coordinate Temporal and Spatial Information Processing in the Olfactory Bulb.Frontiers in computational neuroscience · 2016Article
- Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb.PloS one · 2016Article
- Disinhibition of olfactory bulb granule cells accelerates odour discrimination in mice.Nature communications · 2015Article
- Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Synaptic clusters function as odor operators in the olfactory bulb.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb.Nature neuroscience · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GABAergic granule cells (GCs) regulate, via mitral cells, the final output from the olfactory bulb to piriform cortex and are central for the speed and accuracy of odour discrimination. However, little is known about the local circuits in which GCs are embedded and how GCs respond during functional network activity. We recorded inhibitory and excitatory currents evoked during a single sniff-like odour presentation in GCs in vivo. We found that synaptic excitation was extensively activated across cells, whereas phasic inhibition was rare. Furthermore, our analysis indicates that GCs are innervated by a persistent firing of deep short axon cells that mediated the inhibitory evoked responses. Blockade of GABAergic synaptic input onto GCs revealed a tonic inhibitory current mediated by furosemide-sensitive GABA(A) receptors. The average current associated with this tonic GABAergic conductance was 3-fold larger than that of phasic inhibitory postsynaptic currents. We show that the pharmacological blockage of tonic inhibition markedly increased the occurrence of supra-threshold responses during an odour-stimulated sniff. Our findings suggest that GCs mediate recurrent or lateral inhibition, depending on the ambient level of extracellular GABA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.