ArticleAntimicrobial agents and chemotherapy2013
A new local variant (ST764) of the globally disseminated ST5 lineage of hospital-associated methicillin-resistant Staphylococcus aureus (MRSA) carrying the virulence determinants of community-associated MRSA.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 71 citations in OpenAlex.
- Phylogenomic analysis of a methicillin-resistantMicrobial genomics · 2026Article
- Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage.The Journal of infectious diseases · 2026Article
- Zoonotic potential of methicillin-resistant Staphylococcus aureus isolated from pets and their owners in Bangladesh.Scientific reports · 2025Article
- Article
- Molecular Characterization of Clinical Isolates of Methicillin-ResistantPathogens (Basel, Switzerland) · 2025Article
- Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data.Nature communications · 2025Article
- Two codependent routes lead to high-level MRSA.Science (New York, N.Y.) · 2024Article
- Observational
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Phylogenetic analysis and virulence characteristics of methicillin-resistantEmerging microbes & infections · 2023Article
- Dissemination of Methicillin-Resistant Staphylococcus aureus Sequence Type 764 Isolates with Mupirocin Resistance in China.Microbiology spectrum · 2023Article
- Diversity and Dissemination of Methicillin-ResistantTropical medicine and infectious disease · 2022Review
- Molecular characterization of methicillin-resistant Staphylococcus aureus genotype ST764-SCCmec type II in Thailand.Scientific reports · 2022Article
- Article
- Case Report: Necrotizing fasciitis caused byFrontiers in genetics · 2022Article
- Prevalence and WGS-based characteristics of MRSA isolates in hospitals in Shanghai, China.Frontiers in microbiology · 2022Article
- Prevalence and molecular characterization of methicillin-resistant Staphylococcus aureus with mupirocin, fusidic acid and/or retapamulin resistance.BMC microbiology · 2020Article
- Linezolid and Rifampicin Combination to CombatFrontiers in microbiology · 2019Article
- Article
- Novel Structures and Temporal Changes of Arginine Catabolic Mobile Elements in Methicillin-Resistant Staphylococcus aureus Genotypes ST5-MRSA-II and ST764-MRSA-II in Japan.Antimicrobial agents and chemotherapy · 2016Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ST5 lineage of methicillin-resistant Staphylococcus aureus (MRSA) is one of the most globally disseminated hospital-associated MRSA (HA-MRSA) lineages. We isolated a new local variant (designated ST764) over at least 5 years that causes invasive infections, including necrotizing fasciitis, and is carried by medical students, as well as household members. Analysis of the genome sequence of one isolate compared to that of the reference ST5 strain revealed that ST764 had acquired virulence traits similar to those of community-associated MRSA (CA-MRSA) through the acquisition of two new mobile genetic elements, ACMEII and SaPInn54, which carried ACME arcA and the staphylococcal enterotoxin B gene (seb), respectively, and through enhanced expression of cytolytic peptide genes, although ST764 was negative for Panton-Valentine leukocidin. Other differences between ST764 and ST5 included the acquisition of an ACMEII-related cassette (cJR1), prophage φ2NN54, and streptococcal Tn5251 and decreased numbers of copies of Tn554. As for superantigen genes, although the two possessed seg, sei, sem, sen, and seo, ST764 lacked tst, sec, sel, and sep. The data suggest that ST764 MRSA is a novel hybrid variant of ST5 HA-MRSA with the characteristics of CA-MRSA and that the evolution of ST764 includes multiple steps, e.g., acquisition of novel or nonstaphylococcal mobile elements.
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