ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2012
Three-dimensional organisation of RNA-processing machinery in avian growing oocyte nucleus.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- The 3D genomics of lampbrush chromosomes highlights the role of active transcription in chromatin organization.Nucleic acids research · 2026Article
- The first chicken oocyte nucleus whole transcriptomic profile defines the spectrum of maternal mRNA and non-coding RNA genes transcribed by the lampbrush chromosomes.Nucleic acids research · 2024Article
- Assignment of the somatic A/B compartments to chromatin domains in giant transcriptionally active lampbrush chromosomes.Epigenetics & chromatin · 2023Article
- Single-Cell DNA Methylation Analysis of Chicken Lampbrush Chromosomes.International journal of molecular sciences · 2022Article
- Article
- Dynamics of the Transcriptome and Accessible Chromatin Landscapes During Early Goose Ovarian Development.Frontiers in cell and developmental biology · 2020Article
- Identification of Genomic Loci Responsible for the Formation of Nuclear Domains Using Lampbrush Chromosomes.Non-coding RNA · 2019Review
- Transcription of highly repetitive tandemly organized DNA in amphibians and birds: A historical overview and modern concepts.RNA biology · 2016Review
- Low-voltage scanning electron microscopy study of lampbrush chromosomes and nuclear bodies in avian and amphibian oocytes.Scientific reports · 2016Article
- Giant poly(A)-rich RNP aggregates form at terminal regions of avian lampbrush chromosomes.Chromosoma · 2016Article
- Article
- Nuclear actin depolymerization in transcriptionally active avian and amphibian oocytes leads to collapse of intranuclear structures.Nucleus (Austin, Tex.)Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome architecture and assorted nuclear compartments play an essential role in RNA transcription and processing. Growing vertebrate oocytes represent an advantageous model to study the principles of nuclear structure and function. In this article, the data on three-dimensional (3D) organisation of intact and non-deformed oocyte nuclei (germinal vesicles) in four species of birds (domestic chicken, Japanese quail, rock pigeon and chaffinch) obtained by confocal laser scanning microscopy are presented. The nucleus of the growing avian oocyte has an unusual structure of RNA processing machinery. Germinal vesicles from any of the avian species studied, with the exception of the rock pigeon, are characterized by absence of extrachromosomal RNA-enriched nuclear bodies including Cajal bodies, histone locus bodies and interchromatin granule clusters. The absence of Cajal bodies and histone locus bodies in chicken oocytes correlated with the inactivation of nucleolus organizer and clustered histone genes. Splicing factors such as SR-protein SC35 accumulated in chromosome-associated domains that were classified as complex loops (terminal giant and lumpy loops). Formation of such depot in avian oocyte nuclei is supposed to be nucleated by transcripts of non-coding tandem repeats. The results obtained strongly support a model of RNA-mediated nuclear domains formation.
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