ArticleProceedings of the Japan Academy. Series B, Physical and biological sciences2013
Circadian clock-controlled diurnal oscillation of Ras/ERK signaling in mouse liver.
Article in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- FAM43B mediates BMAL1-driven regulation of ERK signaling to promote cervical cancer progression.Journal of molecular histology · 2026Article
- Integrated Analysis ofBiomolecules · 2026Article
- The circadian architecture of tumor immunity: mechanistic insights and treatment strategies.Biomarker research · 2026Review
- The Circadian Rhythm Regulates the Hepato-ovarian Axis Linking Polycystic Ovary Syndrome and Non-alcoholic Fatty Liver Disease.Biochemical genetics · 2026Article
- Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development.Cell death & disease · 2022Article
- Article
- Core-Clock Genes Regulate Proliferation and Invasion via a Reciprocal Interplay with MACC1 in Colorectal Cancer Cells.Cancers · 2022Article
- MiR-27a-3p promotes the osteogenic differentiation by activating CRY2/ERK1/2 axis.Molecular medicine (Cambridge, Mass.) · 2021Article
- Regulation of Circadian Genes by the MAPK Pathway: Implications for Rapid Antidepressant Action.Neuroscience bulletin · 2020Review
- Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.Nature communications · 2017Article
- The small G protein RAS2 is involved in the metabolic compensation of the circadian clock in the circadian modelThe Journal of biological chemistry · 2017Article
- Circadian rhythm of intracellular protein synthesis signaling in rat cardiac and skeletal muscles.Biochemistry and biophysics reports · 2017Article
- Ras Activity Tunes the Period and Modulates the Entrainment of the Suprachiasmatic Clock.Frontiers in neurology · 2017Review
- CLUSTERnGO: a user-defined modelling platform for two-stage clustering of time-series data.Bioinformatics (Oxford, England) · 2016Article
- Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in Cancer.Frontiers in cell and developmental biology · 2016Review
- Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment.Nature communications · 2014Article
- Diverse roles for MAPK signaling in circadian clocks.Advances in genetics · 2013Review
- The circadian clock in cancer development and therapy.Progress in molecular biology and translational science · 2013Review
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence indicates that ERK MAP kinase signaling plays an important role in the regulation of the circadian clock, especially in the clock-resetting mechanism in the suprachiasmatic nucleus (SCN) in mammals. Previous studies have also shown that ERK phosphorylation exhibits diurnal variation in the SCN. However, little is known about circadian regulation of ERK signaling in peripheral tissues. Here we show that the activity of Ras/ERK signaling exhibits circadian rhythms in mouse liver. We demonstrate that Ras activation, MEK phosphorylation, and ERK phosphorylation oscillate in a circadian manner. As the oscillation of ERK phosphorylation is lost in Cry1/Cry2 double-knockout mice, Ras/ERK signaling should be under the control of the circadian clock. Furthermore, expression of MAP kinase phosphatase-1 (Mkp-1) shows diurnal changes in liver. These results indicate that Ras/ERK signaling is strictly regulated by the circadian clock in liver, and suggest that the circadian oscillation of the activities of Ras, MEK, and ERK may regulate diurnal variation of liver function and/or homeostasis.(Communicated by Shigekazu NAGATA, M.J.A.).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.