ArticleAppetite2013
Differential effects of chronic social stress and fluoxetine on meal patterns in mice.
Article in Appetite, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Temporal control of eating and body weight by GHSR-expressing suprachiasmatic nucleus neurons.Cell reports · 2025Article
- An Emerging Role for Gut-Brain Signaling Involving Ghrelin in Chronic Stress.Advances in experimental medicine and biology · 2025Review
- The intersection between ghrelin, metabolism and circadian rhythms.Nature reviews. Endocrinology · 2024Review
- Article
- "Sibling" battle or harmony: crosstalk between nesfatin-1 and ghrelin.Cellular and molecular life sciences : CMLS · 2022Review
- Ghrelin Receptor Signaling Is Not Required for Glucocorticoid-Induced Obesity in Male Mice.Endocrinology · 2020Article
- β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours.Neurobiology of stress · 2018Article
- Ghrelin is a persistent biomarker for chronic stress exposure in adolescent rats and humans.Translational psychiatry · 2018Article
- The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF.Scientific reports · 2018Article
- Central Ghrelin Resistance Permits the Overconsolidation of Fear Memory.Biological psychiatry · 2017Article
- Stress, overeating, and obesity: Insights from human studies and preclinical models.Neuroscience and biobehavioral reviews · 2017Review
- The Dichotomous Effect of Chronic Stress on Obesity.Trends in endocrinology and metabolism: TEM · 2016Review
- Chronic and acute effects of stress on energy balance: are there appropriate animal models?American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- Influence of Aging and Gender Differences on Feeding Behavior and Ghrelin-Related Factors during Social Isolation in Mice.PloS one · 2015Article
- The use of animal models to decipher physiological and neurobiological alterations of anorexia nervosa patients.Frontiers in endocrinology · 2015Review
- CRF and urocortin peptides as modulators of energy balance and feeding behavior during stress.Frontiers in neuroscience · 2014Review
- Mood, food, and obesity.Frontiers in psychology · 2014Review
- How might circadian rhythms control mood? Let me count the ways...Biological psychiatry · 2013Review
- Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.Molecular metabolism · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Both chronic stress and antidepressant medications have been associated with changes in body weight. In the current study, we investigate mechanisms by which stress and antidepressants interact to affect meal patterns. A group of mice was subjected to the chronic social defeat stress model of major depression followed by fluoxetine treatment and was subsequently analyzed for food intake using metabolic cages. We report that chronic social defeat stress increases food intake by specifically increasing meal size, an effect that is reversed by fluoxetine treatment. In an attempt to gain mechanistic insight into changes in meal patterning induced by stress and fluoxetine, fasting serum samples were collected every 4h over a 24-h period, and acyl-ghrelin, leptin, and corticosterone levels were measured. Chronic stress induces a peak in acyl-ghrelin levels just prior to the onset of the dark phase, which is shifted in mice treated with fluoxetine. Taken together, these results indicate that stress increases food intake by decreasing satiation, and that fluoxetine can reverse stress-induced changes in meal patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.