ArticleDevelopment (Cambridge, England)2013
pbx is required for pole and eye regeneration in planarians.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- 4D single-cell spatial transcriptomics reveals dynamic morphogenetic gradients and regenerative domains in planarians.GigaScience · 2026Article
- Developmental onset of planarian whole-body regeneration depends on axis reset.Current biology : CB · 2025Article
- LIM-HD transcription factors control axial patterning and specify distinct neuronal and intestinal cell identities in planarians.Open biology · 2023Article
- Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.Nature communications · 2023Article
- A Wnt11 and Dishevelled signaling pathway acts prior to injury to control wound polarization for the onset of planarian regeneration.Current biology : CB · 2022Article
- Src acts with WNT/FGFRL signaling to pattern the planarian anteroposterior axis.Development (Cambridge, England) · 2022Article
- Principles of regeneration revealed by the planarian eye.Current opinion in cell biology · 2021Review
- Transcription Factors Active in the Anterior Blastema ofBiomolecules · 2021Article
- STRIPAK Limits Stem Cell Differentiation of a WNT Signaling Center to Control Planarian Axis Scaling.Current biology : CB · 2020Article
- Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis.eLife · 2019Article
- 'Building a perfect body': control of vertebrate organogenesis by PBX-dependent regulatory networks.Genes & development · 2019Review
- Neoblast-enriched zinc finger protein FIR1 triggers local proliferation during planarian regeneration.Protein & cell · 2019Article
- Review
- PHRED-1 is a divergent neurexin-1 homolog that organizes muscle fibers and patterns organs during regeneration.Developmental biology · 2017Article
- Integrin suppresses neurogenesis and regulates brain tissue assembly in planarian regeneration.Development (Cambridge, England) · 2017Article
- Adhesive organ regeneration in Macrostomum lignano.BMC developmental biology · 2016Article
- Go ahead, grow a head! A planarian's guide to anterior regeneration.Regeneration (Oxford, England) · 2016Review
- Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration.eLife · 2016Article
- Forkhead containing transcription factor Albino controls tetrapyrrole-based body pigmentation in planarian.Cell discovery · 2016Article
- SmedGD 2.0: The Schmidtea mediterranea genome database.Genesis (New York, N.Y. : 2000) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Planarian regeneration involves regionalized gene expression that specifies the body plan. After amputation, planarians are capable of regenerating new anterior and posterior poles, as well as tissues polarized along the anterior-posterior, dorsal-ventral and medial-lateral axes. Wnt and several Hox genes are expressed at the posterior pole, whereas Wnt inhibitory genes, Fgf inhibitory genes, and prep, which encodes a TALE-family homeodomain protein, are expressed at the anterior pole. We found that Smed-pbx (pbx for short), which encodes a second planarian TALE-family homeodomain transcription factor, is required for restored expression of these genes at anterior and posterior poles during regeneration. Moreover, pbx(RNAi) animals gradually lose pole gene expression during homeostasis. By contrast, pbx was not required for initial anterior-posterior polarized responses to wounds, indicating that pbx is required after wound responses for development and maintenance of poles during regeneration and homeostatic tissue turnover. Independently of the requirement for pbx in pole regeneration, pbx is required for eye precursor formation and, consequently, eye regeneration and eye replacement in homeostasis. Together, these data indicate that pbx promotes pole formation of body axes and formation of regenerative progenitors for eyes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.