Evidence map›Paper›PMID 23318559›Full record

Trial reportThe American journal of psychiatry2013

Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.

Randal G Ross, Sharon K Hunter, Lizbeth McCarthy, Julie Beuler, Amanda K Hutchison, Brandie D Wagner, Sherry Leonard, Karen E Stevens, Robert Freedman

Erratum issuedOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 97 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 6 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 6 syntheses or guidelines pooled it, 160 citations in OpenAlex.

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  9. Prenatal choline supplementation improves child sustained attention: A 7-year follow-up of a randomized controlled feeding trial.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Randal G RossDepartment of Psychiatry, Obstetrics and Gynecology, University of Colorado Denver, Aurora, USA. randy.ross@ucdenver.edu
Sharon K Hunter
Lizbeth McCarthy
Julie Beuler
Amanda K Hutchison
Brandie D Wagner
Sherry Leonard
Karen E Stevens
Robert Freedman
University of Colorado Hospital · US

Funding

STATISTICAL GENETICS AND TREATMENT ANALYSISP50MH086383 · NIMH · UNIVERSITY OF COLORADO DENVER · PI FREEDMAN, ROBERT · 2009 to 2013
$10.6M
SMOOTH PURSUIT EYE MOVEMENTS--CHILDREN OF SCHIZOPHRENICSR01MH056539 · NIMH · UNIVERSITY OF COLORADO DENVER · PI ROSS, RANDAL G · 1997 to 2008
$1.8M
NIMH NIH HHS P50 MH086383NIMH NIH HHS P50MH086383NIMH NIH HHS R01 MH056539NIMH NIH HHS R01MH056539
6 · The paper itself

Abstract

objectiveDeficient cerebral inhibition is a pathophysiological brain deficit related to poor sensory gating and attention in schizophrenia and other disorders. Cerebral inhibition develops perinatally, influenced by genetic and in utero factors. Amniotic choline activates fetal α7-nicotinic acetylcholine receptors and facilitates development of cerebral inhibition. Increasing this activation may protect infants from future illness by promoting normal brain development. The authors investigated the effects of perinatal choline supplementation on the development of cerebral inhibition in human infants.

methodA randomized placebo-controlled clinical trial of dietary phosphatidylcholine supplementation was conducted with 100 healthy pregnant women, starting in the second trimester. Supplementation to twice normal dietary levels for mother or newborn continued through the third postnatal month. All women received dietary advice regardless of treatment. Infants' electrophysiological recordings of inhibition of the P50 component of the cerebral evoked response to paired sounds were analyzed. The criterion for inhibition was suppression of the amplitude of the second P50 response by at least half, compared with the first response.

resultsNo adverse effects of choline were observed in maternal health and delivery, birth, or infant development. At the fifth postnatal week, the P50 response was suppressed in more choline-treated infants (76%) compared with placebo-treated infants (43%) (effect size=0.7). There was no difference at the 13th week. A CHRNA7 genotype associated with schizophrenia was correlated with diminished P50 inhibition in the placebo-treated infants, but not in the choline-treated infants.

conclusionsNeonatal developmental delay in inhibition is associated with attentional problems as the child matures. Perinatal choline activates timely development of cerebral inhibition, even in the presence of gene mutations that otherwise delay it.

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAttentionBrainChild, PreschoolCholineDNA Mutational AnalysisElectroencephalographyFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenotypeHumansInfantInfant, NewbornMaleNeural Inhibitionalpha7 Nicotinic Acetylcholine ReceptorCholineChrna7 protein, humanNootropic AgentsPhosphorylcholineReceptors, Nicotinic

Identifiers

PMID23318559
PMCPMC3640283
OpenAlexW2170922033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.