Evidence map›Paper›PMID 23318442›Full record

ArticleOncogene2014

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program.

C Chauvin, V Koka, A Nouschi, V Mieulet, C Hoareau-Aveilla, A Dreazen, N Cagnard, W Carpentier, T Kiss, O Meyuhas and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 1 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 1 synthesis or guideline pooled it, 274 citations in OpenAlex.

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  13. Ribosome-associated proteins: unwRAPping ribosome heterogeneity in the twenty-first century.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
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105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

C Chauvin1] INSERM, U845, Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, UMRS-845, Paris, France.
V Koka1] INSERM, U845, Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, UMRS-845, Paris, France.
A Nouschi1] INSERM, U845, Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, UMRS-845, Paris, France.
V Mieulet1] INSERM, U845, Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, UMRS-845, Paris, France.
C Hoareau-AveillaLaboratoire de Biologie Moléculaire Eucaryote, Université de Toulouse-UPS and Centre National de La Recherche Scientifique, Toulouse, France.
A DreazenDepartment of Biochemistry and Molecular Biology, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
N CagnardUniversité Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, UMRS-845, Paris, France.
W CarpentierPlateforme Post-Génomique Pitié-Salpétrière, Groupe Hospitalier Pitié-Salpétrière, Université Pierre et Marie Curie, Paris, France.
T KissLaboratoire de Biologie Moléculaire Eucaryote, Université de Toulouse-UPS and Centre National de La Recherche Scientifique, Toulouse, France.
O MeyuhasDepartment of Biochemistry and Molecular Biology, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
M Pende1] INSERM, U845, Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, UMRS-845, Paris, France.
Université Paris Cité · FRDélégation Paris 5 · FRInserm · FRLaboratoire de Biologie Moléculaire des Eucaryotes · FRSorbonne Paris Cité · FRSorbonne Université · FRUniversité Toulouse III - Paul Sabatier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

S6 kinases (S6Ks) are mechanistic target of rapamycin substrates that participate in cell growth control. S6Ks phosphorylate ribosomal protein S6 (rpS6) and additional proteins involved in the translational machinery, although the functional roles of these modifications remain elusive. Here we analyze the S6K-dependent transcriptional and translational regulation of gene expression by comparing whole-genome microarray of total and polysomal mouse liver RNA after feeding. We show that tissue lacking S6Ks 1 and 2 (S6K1 and S6K2), displays a defect in the ribosome biogenesis (RiBi) transcriptional program after feeding. Over 75% of RiBi factors are controlled by S6K, including Nop56, Nop14, Gar1, Rrp9, Rrp15, Rrp12 and Pwp2 nucleolar proteins. Importantly, the reduced activity of RiBi transcriptional promoters in S6K1;S6K2(-/-) cells is also observed in rpS6 knock-in mutants that cannot be phosphorylated. As ribosomal protein synthesis is not affected by these mutations, our data reveal a distinct and specific aspect of RiBi under the control of rpS6 kinase activity, that is, the RiBi transcriptional program.

Indexed as

AnimalsBlotting, NorthernBlotting, WesternGene Knock-In TechniquesMiceMice, Inbred C57BLMice, KnockoutOligonucleotide Array Sequence AnalysisPhosphorylationProtein BiosynthesisReal-Time Polymerase Chain ReactionRibosomal Protein S6Ribosomal Protein S6 KinasesRibosomesTranscription, GeneticTranscriptomeRibosomal Protein S6Ribosomal Protein S6 Kinases

Identifiers

PMID23318442
OpenAlexW2043042113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.