ArticleNeurobiology of aging2013
Sortilin receptor 1 predicts longitudinal cognitive change.
Article in Neurobiology of aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- A meta-analysis of heritability of cognitive aging: minding the "missing heritability" gap.Neuropsychology review · 2015Pooled it
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- WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling.bioRxiv : the preprint server for biology · 2025Article
- Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.Brain : a journal of neurology · 2022Article
- Measuring heritable contributions to Alzheimer's disease: polygenic risk score analysis with twins.Brain communications · 2022Article
- Genetic Insights into Alzheimer's Disease.Annual review of pathology · 2021Review
- [Verification of a sporadic Alzheimer disease model in SORL1 gene knockout mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age.Journal of Alzheimer's disease : JAD · 2018Article
- SORL1 rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals.European journal of neurology · 2017Article
- SORL1 gene, plasma biomarkers, and the risk of Alzheimer's disease for the Han Chinese population in Taiwan.Alzheimer's research & therapy · 2016Article
- Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.Acta neuropathologica · 2016Review
- Article
- Anxiety is associated with increased risk of dementia in older Swedish twins.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Article
- Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan.Scientific reports · 2016Article
- G×E Interaction Influences Trajectories of Hand Grip Strength.Behavior genetics · 2016Article
- Gene-Environment Interplay in Physical, Psychological, and Cognitive Domains in Mid to Late Adulthood: Is APOE a Variability Gene?Behavior genetics · 2016Article
- Sex moderates the effects of the Sorl1 gene rs2070045 polymorphism on cognitive impairment and disruption of the cingulum integrity in healthy elderly.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Sex differences in cognitive impairment and Alzheimer's disease.Frontiers in neuroendocrinology · 2014Review
- Associations of Germline Genetic Variants With Depression and Fatigue Among Hematologic Cancer Patients Treated With Allogeneic Hematopoietic Cell Transplantation.Psychosomatic medicineArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The gene encoding sortilin receptor 1 (SORL1) has been associated with Alzheimer's disease risk. We examined 15 SORL1 variants and single nucleotide polymorphism (SNP) set risk scores in relation to longitudinal verbal, spatial, memory, and perceptual speed performance, testing for age trends and sex-specific effects. Altogether, 1609 individuals from 3 population-based Swedish twin studies were assessed up to 5 times across 16 years. Controlling for apolipoprotein E genotype (APOE), multiple simple and sex-moderated associations were observed for spatial, episodic memory, and verbal trajectories (p = 1.25E-03 to p = 4.83E-02). Five variants (rs11600875, rs753780, rs7105365, rs11820794, rs2070045) were associated across domains. Notably, in those homozygous for the rs2070045 risk allele, men demonstrated initially favorable performance but accelerating declines, and women showed overall lower performance. SNP set risk scores predicted spatial (Card Rotations, p = 5.92E-03) and episodic memory trajectories (Thurstone Picture Memory, p = 3.34E-02), where higher risk scores benefited men's versus women's performance up to age 75 but with accelerating declines. SORL1 is associated with cognitive aging, and might contribute differentially to change in men and women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.