Evidence map›Paper›PMID 23318050›Full record

Trial reportMetabolism: clinical and experimental2013

Resistance training increases SHBG in overweight/obese, young men.

Christian K Roberts, Daniel M Croymans, Najib Aziz, Anthony W Butch, Cathy C Lee

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Metabolism: clinical and experimental, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Review
  10. Article
  11. Review
  12. Obesity Animal Models for Acupuncture and Related Therapy Research Studies.Evidence-based complementary and alternative medicine : eCAM · 2021
    Review
  13. Various Factors May Modulate the Effect of Exercise on Testosterone Levels in Men.Journal of functional morphology and kinesiology · 2020
    Review
  14. Article
  15. Article
  16. Article
  17. Obesity and Physical Activity.Journal of obesity & metabolic syndrome · 2017
    Review
  18. Review
  19. Sex Hormone-Binding Globulin in Children and Adolescents.Journal of clinical research in pediatric endocrinology · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Christian K RobertsExercise and Metabolic Disease Research Laboratory, Translational Sciences Section, UCLA School of Nursing, University of California, Los Angeles, CA, USA. croberts@ucla.edu
Daniel M Croymans
Najib Aziz
Anthony W Butch
Cathy C Lee
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Vascular function, cardiovascular disease biomarkers and the Latino paradoxP50HL105188 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAPLAN, ROBERT M · 2010 to 2014
$9.9M
Glycemic Load and Resistance Training on Endothelial Function and InflammationR01DK090406 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARPENTER, CATHERINE L, GO, VAY LIANG W · 2011 to 2014
$2.7M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NHLBI NIH HHS P50 HL105188NIDDK NIH HHS DK090406NIDDK NIH HHS R01 DK090406
6 · The paper itself

Abstract

objectiveEvidence suggests that SHBG affects glycemic control, predicts both T2D and metabolic syndrome, and is low in obese subjects. We sought to determine if resistance exercise training (RT) can increase sex hormone-binding globulin (SHBG) and ameliorate levels of related steroid hormones in overweight/obese, sedentary young men. MATERIALS/

methods36 participants (BMI 31.4 kg/m(2), age 22 years) were randomized into an RT (12 weeks of training, 3/week) or control group (C, 12 weeks no training), and assessed for changes in SHBG, cortisol, testosterone, free testosterone (FT) and free androgen index (FAI). In addition, body composition and oral glucose tolerance testing was performed.

results12 weeks of RT increased SHBG (P=0.01) and decreased FAI (P<0.05) and cortisol (P<0.05) compared to C. FT decreased in RT (P=0.01). Total testosterone did not change in either group. These changes were noted without weight loss, and in concert with increases in lean body mass (P=0.0002 vs C) and decreases in glucose area under the curve (AUC) (P=0.004), insulin AUC (P=0.03), and total (P=0.002) and trunk (P=0.003) fat mass in RT.

conclusionIn overweight/obese young men, RT increases SHBG and lowers FAI in obese young adult men.

Indexed as

Resistance TrainingAdolescentAdultAlgorithmsBody CompositionHumansMaleMuscle StrengthObesityOverweightSex FactorsSex Hormone-Binding GlobulinTestosteroneUp-RegulationYoung AdultSex Hormone-Binding GlobulinTestosterone

Identifiers

PMID23318050
PMCPMC3845495
OpenAlexW2038307706

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.