ReviewCurrent opinion in genetics & development2013
The piRNA pathway in flies: highlights and future directions.
Review in Current opinion in genetics & development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed.
- Article
- Article
- Daphnia magna egg piRNA cluster expression profiles change as mothers age.BMC genomics · 2022Article
- PiRNA Biogenesis and Their Role in Human Cancers and Other Diseases: A Narrative Review.Iranian journal of public health · 2021Review
- The function and regulation mechanism of piRNAs in human cancers.Histology and histopathology · 2021Review
- Review
- Insights Into an Unexplored Component of the Mosquito Repeatome: Distribution and Variability of Viral Sequences Integrated Into the Genome of the Arboviral VectorFrontiers in genetics · 2019Article
- A role for MED14 and UVH6 in heterochromatin transcription upon destabilization of silencing.Life science alliance · 2018Article
- Transposon silencing in theLife science alliance · 2018Article
- piRNA Profiling of Dengue Virus Type 2-Infected Asian Tiger Mosquito and Midgut Tissues.Viruses · 2018Article
- Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster.BMC developmental biology · 2018Review
- Review
- piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm.Nature communications · 2017Article
- Aubergine and piRNAs promote germline stem cell self-renewal by repressing the proto-oncogeneThe EMBO journal · 2017Article
- The RNAi Inheritance Machinery ofGenetics · 2017Article
- Integrative analysis unveils new functions for theRNA (New York, N.Y.) · 2017Article
- Article
- Analysis of chikungunya virus proteins reveals that non-structural proteins nsP2 and nsP3 exhibit RNA interference (RNAi) suppressor activity.Scientific reports · 2016Article
- Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila.PLoS genetics · 2016Article
- TALE-light imaging reveals maternally guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos.Genes & development · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Piwi proteins, together with their bound Piwi-interacting RNAs, constitute an evolutionarily conserved, germline-specific innate immune system. The piRNA pathway is one of the key mechanisms for silencing transposable elements in the germline, thereby preserving genome integrity between generations. Recent work from several groups has significantly advanced our understanding of how piRNAs arise from discrete genomic loci, termed piRNA clusters, and how these Piwi-piRNA complexes enforce transposon silencing. Here, we discuss these recent findings, as well as highlight some aspects of piRNA biology that continue to escape our understanding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.