ArticleCough (London, England)2013
Clinical experience with low-dose itraconazole in chronic idiopathic cough.
Article in Cough (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Tools for assessing outcomes in studies of chronic cough: CHEST guideline and expert panel report.Chest · 2015Guideline
- Infectious and Inflammatory Pathways to Cough.Annual review of physiology · 2023Review
- Article
- Bronchiectasis and cough: An old relationship in need of renewed attention.Pulmonary pharmacology & therapeutics · 2019Review
- Psychometric properties of the German version of the Leicester Cough Questionnaire in sarcoidosis.PloS one · 2018Article
- Atopic cough and fungal allergy.Journal of thoracic disease · 2014Review
- Specific detection of Bjerkandera adusta by polymerase chain reaction and its incidence in fungus-associated chronic cough.Mycopathologia · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundThe presence of basidiomycetous (BM) fungi in induced sputum is an important clinical finding in chronic idiopathic cough (CIC). However, the efficacy of anti-fungal therapy for CIC has not been evaluated.
methodsWe selected 10 patients with CIC and carried out allergological examinations for Bjerkandera adusta, a BM fungus that has been shown to enhance cough severity. The efficacy of low-dose itraconazole (ITCZ) therapy (50 mg/day) for 14 days as an adjunctive therapy was estimated with use of Cough Visual Analog Scale (Cough VAS) and the Japanese version of the Leicester Cough Questionnaire (J-LCQ). We evaluated whether there was a recognizable clinical or allergological pattern that could predict the efficacy of ITCZ therapy in CIC patients.
resultsSignificant changes in Cough VAS and minimal important difference in domains of the J-LCQ were observed in 3 and 5 CIC patients, respectively. The Δ cough scale was correlated with changes in domains of the J-LCQ (total (r = -0.73, P < 0.05), psychological (r = -0.73, P < 0.05), and social (r = -0.71, P < 0.05), respectively. There were significant differences in the change in total score (P < 0.05) and in the domain of social (P < 0.05) and Δ cough scale (P < 0.05) between positive and negative results of immediate skin test for B. adusta. Positive results for improvement of cough-related laryngeal sensation which was represented as a sensation of mucus in the throat (SMIT) were observed in 6 patients in the BM colonization-positive group (85.7%) and none in the BM colonization-negative group (0%). There was a significant difference in the positive ratio for improvement of SMIT between the two groups.
conclusionsAt present, it is not possible to conclude whether ITCZ therapy provides sufficient relief in CIC patients. However, this study suggested both the possible applicability of low-dose ITCZ therapy for treatment of CIC patients with regard to BM allergy and the necessity of development of a new assessment questionnaire for cough-related laryngeal sensations.
trial registrationUMIN-CTR (reference number R000005872; UMIN000004933).
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