ArticleCurrent eye research2013
Quantitative retinal and choroidal blood flow during light, dark adaptation and flicker light stimulation in rats using fluorescent microspheres.
Article in Current eye research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- Short-term effects of sunlight exposure on fundus blood flow perfusion in children: a randomised controlled trial.The British journal of ophthalmology · 2024Trial
- Action potential propagation in the rodent myelinated optic nerve does not trigger neurovascular coupling.Nature communications · 2026Article
- Acute Ocular Hypertension Diminishes Flicker-Induced Enhancement in Retinal Blood Flow and Full-Field Electroretinogram in a Mouse Model.Investigative ophthalmology & visual science · 2026Article
- Effects of flickering light stimulation on retinal blood flow and full-field electroretinogram in mice.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Light-sensitive CaProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spectral fiber photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity.Cell reports methods · 2022Article
- Computing hemodynamic response functions from concurrent spectral fiber-photometry and fMRI data.Neurophotonics · 2022Article
- An isotropic EPI database and analytical pipelines for rat brain resting-state fMRI.NeuroImage · 2021Article
- Measurement of Retinal Microvascular Blood Velocity Using Erythrocyte Mediated Velocimetry.Scientific reports · 2019Article
- Hemodynamic Response of the Three Macular Capillary Plexuses in Dark Adaptation and Flicker Stimulation Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2019Article
- Retinal tissue oxygen tension and consumption during light flicker stimulation in rat.Experimental eye research · 2018Article
- Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood.Addiction biology · 2018Article
- Retinal oxygen: from animals to humans.Progress in retinal and eye research · 2017Review
- Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Functional circuit mapping of striatal output nuclei using simultaneous deep brain stimulation and fMRI.NeuroImage · 2017Article
- Resting state network topology of the ferret brain.NeuroImage · 2016Article
- Melanopsin Phototransduction Contributes to Light-Evoked Choroidal Expansion and Rod L-Type Calcium Channel Function In Vivo.Investigative ophthalmology & visual science · 2016Article
- Dynamic contrast optical coherence tomography images transit time and quantifies microvascular plasma volume and flow in the retina and choriocapillaris.Biomedical optics express · 2016Article
- Functional Magnetic Resonance Imaging of Electrical and Optogenetic Deep Brain Stimulation at the Rat Nucleus Accumbens.Scientific reports · 2016Article
- Effects of Dorzolamide on Retinal and Choroidal Blood Flow in the DBA/2J Mouse Model of Glaucoma.Investigative ophthalmology & visual science · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThe present study aimed to quantify retinal and choroidal blood flow (BF) during light, dark adaptation and flicker light stimulation using the microsphere technique. MATERIALS AND
methodsAdult male Sprague-Dawley rats were anesthetized with isoflurane. Eyes were dark (Group I, n = 8), light (Group II, n = 8) adapted or stimulated with 10 Hz flicker light (Group III, n = 10). Retinal and choroidal BF were measured by a previously established method, using a mixture of 8 µm yellow-green and 10 µm red fluorescent microspheres. The microspheres were counted ex vivo in the dissected retina and choroid and in the reference arterial blood under a fluorescent microscope.
resultsThe choroidal BF was 64.8 ± 29 µl/min (mean ± SD) during dark adaptation, not significantly different from that during light adaptation (66.0 ± 17.8 µl/min). The retinal BF was 13.5 ± 3.2 µl/min during 10 Hz flickering light stimulation, significantly higher than that during dark adaptation in the control fellow eyes (9.9 ± 2.9 µl/min). The choroidal BF values were not statistically different between flicker stimulation and dark adaptation. Retinal BF was 11.6 ± 2.9 µl/min during light adaptation. Dark adaptation did not increase retinal BF (Group I, 8.2 ± 2.4 µl/min; Group II, 9.9 ± 2.9 µl/min).
conclusionsThese findings argue against a dark-induced or flicker-induced functional hyperemia in the choroid as a result of the demands of the outer retina. Retinal BF was not higher during dark adaptation. Our data support the conclusion that the inner retina has a higher energy demand in flicker conditions relative to dark.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.