ArticleBMC research notes2013
Elevated levels of whole blood nickel in a group of Sri Lankan women with endometriosis: a case control study.
Article in BMC research notes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Endometriosis and irritable bowel syndrome: A systematic review and meta-analyses.Frontiers in medicine · 2022Pooled it
- From Environmental to Possible Occupational Exposure to Risk Factors: What Role Do They Play in the Etiology of Endometriosis?International journal of environmental research and public health · 2021Pooled it
- The Effect of N-Acetyl Cysteine on Serum Lipid Profile and Heavy Metals in Women With Endometriosis Undergoing ICSI: A Randomized Controlled Trial.Health science reports · 2026Article
- Diet in Prevention and Treatment of Endometriosis: Current State of Knowledge.Current nutrition reports · 2024Review
- How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?Nutrients · 2024Review
- Urinary cadmium and endometriosis prevalence in a US nationally representative sample: results from NHANES 1999-2006.Human reproduction (Oxford, England) · 2023Article
- Brief Review of Endometriosis and the Role of Trace Elements.International journal of molecular sciences · 2021Review
- Does Exposure of Lead and Cadmium Affect the Endometriosis?International journal of environmental research and public health · 2021Article
- Lead (Pb) exposure assessment in dried blood spots using Total Reflection X-Ray Fluorescence (TXRF).Environmental research · 2021Article
- Article
- Nickel Allergy Is a Risk Factor for Endometriosis: An 11-Year Population-Based Nested Case-Control Study.PloS one · 2015Article
- Cadmium and Reproductive Health in Women: A Systematic Review of the Epidemiologic Evidence.Current environmental health reports · 2014Article
- Biomonitoring of cadmium, chromium, nickel and arsenic in general population living near mining and active industrial areas in Southern Tunisia.Environmental monitoring and assessment · 2014Article
- Trace elements and endometriosis: the ENDO study.Reproductive toxicology (Elmsford, N.Y.) · 2013Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEndometriosis is characterized by the persistence of endometrial tissue in ectopic sites outside the uterine cavity. Presence of nickel, cadmium and lead in ectopic endometrial tissue has been reported previously. While any association between blood levels of nickel and endometriosis is yet to be described in literature, conflicting reports are available with regards to cadmium and lead levels in blood and urine.
findingsIn fifty patients with endometriosis and fifty age-matched controls confirmed by laparoscopy or laparotomy, whole blood samples were collected and digested using supra pure 65% HNO3. Whole blood levels of nickel and lead were measured using Total Reflection X-ray Fluorescence (TXRF) while cadmium levels were evaluated using graphite furnace atomic absorption spectroscopy (GFASS). Women with endometriosis had significantly higher (P=0.016) geometric mean (95% CI) whole blood nickel levels [2.6(1.9-3.3) μg/L] as compared to women without endometriosis [0.8 (0.7-0.9) μg/L]. Whole blood levels of cadmium and lead were similar between the two groups.
conclusionsAlthough women with endometriosis in this study population had higher levels of nickel in whole blood compared to controls, whether nickel could be considered as an aetiological factor in endometriosis remains inconclusive in view of the smaller sample that was evaluated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.