ArticleCardiovascular diabetology2013
Glycemic variability is associated with subclinical atherosclerosis in Chinese type 2 diabetic patients.
Article in Cardiovascular diabetology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Twenty Minute Moderate-Intensity Post-Dinner Exercise Reduces the Postprandial Glucose Response in Chinese Patients with Type 2 Diabetes.Medical science monitor : international medical journal of experimental and clinical research · 2018Trial
- [Effect of moderate exercise for 30 min at 30 min versus 60 min after dinner on glycemic control in patients with type 2 diabetes: a randomized, crossover, self-controlled study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Trial
- Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report.Cardiovascular diabetology · 2018Trial
- Continuous Glucose Monitoring-Derived Metrics and Cardiovascular Risk Among People With Diabetes: Systematic Scoping Review.JMIR diabetes · 2026Review
- Correlation of Carotid Intima-media Thickness with Glycaemic Variability in Patients with Type 2 Diabetes Mellitus: A Cross-sectional Study.Annals of neurosciences · 2025Article
- Association of Glycaemia Risk Index With Indices of Atherosclerosis: A Cross-Sectional Study.Journal of diabetes · 2025Article
- Association between glycemia risk index and arterial stiffness in type 2 diabetes.Journal of diabetes investigation · 2024Article
- Enhancement of Ambulatory Glucose Profile for Decision Assistance and Treatment Adjustments.Diagnostics (Basel, Switzerland) · 2024Article
- Glycemic variability: Measurement, target, impact on complications of diabetes and does it really matter?Journal of diabetes investigation · 2024Review
- Opposite effects of low-carbohydrate high-fat diet on metabolism in humans and mice.Lipids in health and disease · 2023Article
- Visit-to-visit HbA1c variability is associated with aortic stiffness progression in participants with type 2 diabetes.Cardiovascular diabetology · 2023Article
- Association of gamma-glutamyl transferase variability with risk of venous thrombosis.Scientific reports · 2023Article
- Complications of Diabetes and Metrics of Glycemic Management Derived From Continuous Glucose Monitoring.The Journal of clinical endocrinology and metabolism · 2022Review
- The Role of Glycemic Variability in Cardiovascular Disorders.International journal of molecular sciences · 2021Review
- Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study.Diabetologia · 2021Article
- Glucose Fluctuation and Severe Internal Carotid Artery Siphon Stenosis in Type 2 Diabetes Patients.Nutrients · 2021Observational
- Associations of continuous glucose monitoring-assessed glucose variability with intima-media thickness and ultrasonic tissue characteristics of the carotid arteries: a cross-sectional analysis in patients with type 2 diabetes.Cardiovascular diabetology · 2021Observational
- Associations between continuous glucose monitoring-derived metrics and arterial stiffness in Japanese patients with type 2 diabetes.Cardiovascular diabetology · 2021Observational
- Effects of glucose variability on hematopoietic stem/progenitor cells in patients with type 1 diabetes.Journal of endocrinological investigation · 2021Article
- Association of glycemic variability with left ventricular diastolic function in type 2 diabetes mellitus.Cardiovascular diabetology · 2019Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe contribution of glycemic variability to macrovascular complications remains unclear. We therefore investigated the association between glycemic variability and cervical and/or intracranial atherosclerosis in Chinese type 2 diabetic patients.
methodsWe conducted a cross-sectional study in 216 type 2 diabetic patients with a hemoglobin A1c of 8.3 ± 1.7% and a median diabetes duration of 9.0 years. The standard deviation of blood glucose values (SDBG) and the mean amplitude of glycemic excursion (MAGE) were calculated from continuous glucose monitoring system data for assessing glycemic variability while 24h mean blood glucose (MBG) was calculated for measuring overall blood glucose level. Magnetic resonance angiography (MRA) was used to detect cervical and/or intracranial plaque, and ultrasonography was used to quantify carotid intima-media thickness (IMT) as an index of subclinical atherosclerosis.
resultsOne hundred and fifty-three patients (70.8%) presented with cervical and/or intracranial lesions on MRA among 216 patients in the study. Elder age, increased systolic blood pressure, increased MBG and elevated low density lipoprotein cholesterol were independent contributors to plaque formation. In patients without stenosis (n = 63), SDBG (r = 0.412, P = 0.001) and MAGE (r = 0.365, P = 0.005) were both correlated with carotid IMT and these relationships remained significant in multiple linear regression analysis (multiple R2 = 0.314 for the model including SDBG and multiple R2 = 0.268 for the model including MAGE). However, SDBG and MAGE were not significantly different among patients with different stenosis degrees.
conclusionsGlycemic variability is associated with subclinical atherosclerosis in Chinese type 2 diabetic patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.