ArticleISRN gastroenterology2012
What really causes necrotising enterocolitis?
Article in ISRN gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Molecular and Chromatin Accessibility Programs Underlying Epithelial Injury and Impaired Regeneration in Neonatal Necrotizing Enterocolitis.Cellular and molecular gastroenterology and hepatology · 2026Article
- Enteral Feedings Do Not Increase the Risk of NEC in ELBW Infants Undergoing Treatment of Patent Ductus Arteriosus With Acetaminophen.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Article
- The benefits, limitations and opportunities of preclinical models for neonatal drug development.Disease models & mechanisms · 2022Review
- Laparoscopic vs open Ladd's procedure for malrotation in neonates and infants: a propensity score matching analysis.BMC surgery · 2022Article
- Altered Gut Microbiome and Fecal Immune Phenotype in Early Preterm Infants With Leaky Gut.Frontiers in immunology · 2022Article
- When a Neonate Is Born, So Is a Microbiota.Life (Basel, Switzerland) · 2021Review
- Intestinal Microbiota in Common Chronic Inflammatory Disorders Affecting Children.Frontiers in immunology · 2021Review
- Copious amount of bloody stool in a newborn shortly after birth.SAGE open medical case reports · 2021Article
- Necrotising enterocolitis in an adult with anorexia nervosa.Annals of the Royal College of Surgeons of England · 2020Review
- The Risk of Developing Constipation After Neonatal Necrotizing Enterocolitis.Frontiers in pediatrics · 2020Article
- Influence of stress factors on intestinal epithelial injury and regeneration.Pediatric surgery international · 2018Article
- Microbial Biomarkers of Intestinal Barrier Maturation in Preterm Infants.Frontiers in microbiology · 2018Article
- Global hypoxia-ischemia induced inflammation and structural changes in the preterm ovine gut which were not ameliorated by mesenchymal stem cell treatment.Molecular medicine (Cambridge, Mass.) · 2016Article
- Benign pneumoperitoneum in newborns: which abdomen to open and which one to observe?Clinical case reports · 2016Article
- NEC in Twin Pregnancies: Incidence and Outcomes.Journal of neonatal surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. One of the most serious gastrointestinal disorders occurring in neonates is necrotising enterocolitis (NEC). It is recognised as the most common intra-abdominal emergency and is the leading cause of short bowel syndrome. With extremely high mortality and morbidity, this enigmatic disease remains a challenge for neonatologists around the world as its definite aetiology has yet to be determined. As current medical knowledge stands, there is no single well-defined cause of NEC. Instead, there are nearly 20 risk factors that are proposed to increase the likelihood of developing NEC. Aims and Objectives. The aim of this project was to conduct a comprehensive literature review around the 20 or so well-documented and less well-documented risk factors for necrotising enterocolitis. Materials and Methods. Searches of the Medline, Embase, and Science direct databases were conducted using the words "necrotising enterocolitis + the risk factor in question" for example, "necrotising enterocolitis + dehydration." Search results were ordered by relevance with bias given to more recent publications. Conclusion. This literature review has demonstrated the complexity of necrotising enterocolitis and emphasised the likely multifactorial aetiology. Further research is needed to investigate the extent to which each risk factor is implicated in necrotising enterocolitis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.