ReviewJournal of obesity2012
Copy number variants in obesity-related syndromes: review and perspectives on novel molecular approaches.
Review in Journal of obesity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Long-term effects of bariatric surgery in patients with obesity and chromosome 16 p11.2 microdeletion.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2017Trial
- Effect of a diet containing folate and hazelnut oil capsule on the methylation level of theClinical epigenetics · 2017Trial
- Spontaneous Pregravid Obesity Reshapes Fetal Immune Ontogeny in a Nonhuman Primate Model.bioRxiv : the preprint server for biology · 2026Article
- Maternal Obesity Reprograms Differentiation Trajectories of Fetal Hematopoietic Stem and Progenitor Cells Through Altered Inflammatory Signaling.bioRxiv : the preprint server for biology · 2026Article
- Obesity: pathophysiology and therapeutic interventions.Molecular biomedicine · 2025Review
- Clinical and molecular characterisation of children with monogenic obesity: a case series.Pediatric endocrinology, diabetes, and metabolism · 2024Article
- Adipose Tissue, Non-Communicable Diseases, and Physical Exercise: An Imperfect Triangle.International journal of molecular sciences · 2023Review
- GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator.Communications biology · 2023Article
- [From genotype to phenotype: amylase gene in childhood obesity].Revista medica del Instituto Mexicano del Seguro Social · 2023Review
- Reviewed and updated Algorithm for Genetic Characterization of Syndromic Obesity Phenotypes.Current genomics · 2022Review
- Article
- Obesity: Epidemiology, Pathophysiology, and Therapeutics.Frontiers in endocrinology · 2021 · on this mapReview
- CTRP12 ablation differentially affects energy expenditure, body weight, and insulin sensitivity in male and female mice.American journal of physiology. Endocrinology and metabolism · 2020Article
- RANK/RANKL/OPG pathway is an important for the epigenetic regulation of obesity.Molecular biology reports · 2019Article
- The effect of copy number variations in chromosome 16p on body weight in patients with intellectual disability.Journal of human genetics · 2019Article
- Article
- Chromosomal microarray analysis in the genetic evaluation of 279 patients with syndromic obesity.Molecular cytogenetics · 2018Article
- GENETIC AND EPIGENETIC CAUSES OF OBESITY.Adolescent medicine: state of the art reviews · 2017Review
- Partial deficiency of CTRP12 alters hepatic lipid metabolism.Physiological genomics · 2016Article
- Obesity and diabetes: from genetics to epigenetics.Molecular biology reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent decades, obesity has reached epidemic proportions worldwide and became a major concern in public health. Despite heritability estimates of 40 to 70% and the long-recognized genetic basis of obesity in a number of rare cases, the list of common obesity susceptibility variants by the currently published genome-wide association studies (GWASs) only explain a small proportion of the individual variation in risk of obesity. It was not until very recently that GWASs of copy number variants (CNVs) in individuals with extreme phenotypes reported a number of large and rare CNVs conferring high risk to obesity, and specifically deletions on chromosome 16p11.2. In this paper, we comment on the recent advances in the field of genetics of obesity with an emphasis on the genes and genomic regions implicated in highly penetrant forms of obesity associated with developmental disorders. Array genomic hybridization in this patient population has afforded discovery opportunities for CNVs that have not previously been detectable. This information can be used to generate new diagnostic arrays and sequencing platforms, which will likely enhance detection of known genetic conditions with the potential to elucidate new disease genes and ultimately help in developing a next-generation sequencing protocol relevant to clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.