SynthesisJournal of developmental origins of health and disease2013
Early-life conditions and older adult health in low- and middle-income countries: a review.
Synthesis in Journal of developmental origins of health and disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Cognitive impairment and dementia-Are they linked to childhood health and socioeconomic status? A systematic review.PloS one · 2025Pooled it
- Early life circumstances and their impact on health in adulthood and later life: a systematic review.BMC geriatrics · 2024Pooled it
- The Role of Social Determinants of Health in Cardiovascular Diseases: An Umbrella Review.Journal of the American Heart Association · 2023Pooled it
- The influence of early-life conditions on cardiovascular disease later in life among ethnic minority populations: a systematic review.Internal and emergency medicine · 2016Pooled it
- Childhood experiences and adult self-rated physical health in 22 countries.BMC global and public health · 2026Article
- The "long arm of childhood" on mortality in older adulthood in the United States and Brazil: examining the role of educational attainment and differences by gender.American journal of epidemiology · 2026Article
- Article
- Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Effects of Restrictive Abortion Legislation on Cohort Mortality Evidence from 19Journal of public economics · 2025Article
- Postacute Sequelae of SARS-CoV-2 in Children.Pediatrics · 2024Review
- Review
- Childhood and adult socioeconomic status influence on late-life healthy longevity: evidence from the Chinese longitudinal healthy longevity survey.Frontiers in public health · 2024Article
- Exploring the association of lifestyle behaviors and healthy ageing among the older adults in India: evidence from LASI survey.BMC geriatrics · 2023Article
- Does early-life migration experience determine health and health-risk behavior in later life? Evidence from elderly returns migrants in Kerala, India.SSM - population health · 2023Article
- Point-of-care applicable metabotyping using biofluid-specific electrospun MetaSAMPs directly amenable to ambient LA-REIMS.Science advances · 2023Article
- Resilience to stress across the lifespan: Childhood maltreatment, heart rate variability, and bereavement.Psychology and aging · 2023Article
- Re-examining the reversal hypothesis: A nationwide population-based study of the association between socioeconomic status, and NCDs and risk factors in China.SSM - population health · 2023Article
- Article
- A biosocial return to race? A cautionary view for the postgenomic era.American journal of human biology : the official journal of the Human Biology Council · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Population aging and subsequent projected large increases in chronic conditions will be important health concerns in low- and middle-income countries. Although evidence is accumulating, little is known regarding the impact of poor early-life conditions on older adult (50 years and older) health in these settings. A systematic review of 1141 empirical studies was conducted to identify population-based and community studies in low- and middle-income countries, which examined associations between early-life conditions and older adult health. The resulting review of 20 studies revealed strong associations between (1) in utero/early infancy exposures (independent of other early life and adult conditions) and adult heart disease and diabetes; (2) poor nutrition during childhood and difficulties in adult cognition and diabetes; (3) specific childhood illnesses such as rheumatic fever and malaria and adult heart disease and mortality; (4) poor childhood health and adult functionality/disability and chronic diseases; (5) poor childhood socioeconomic status (SES) and adult mortality, functionality/disability and cognition; and (6) parental survival during childhood and adult functionality/disability and cognition. In several instances, associations remained strong even after controlling for adult SES and lifestyle. Although exact mechanisms cannot be identified, these studies reinforce to some extent the importance of early-life environment on health at older ages. Given the paucity of cohort data from the developing world to examine hypotheses of early-life conditions and older adult health, population-based studies are relevant in providing a broad perspective on the origins of adult health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.