ArticleFrontiers in genetics2012
Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Pooled it
- Flexible integration of spatial and expression information for precise spot embedding via ZINB-based graph-enhanced autoencoder.Communications biology · 2025Article
- Association between theMicrobiology spectrum · 2025Article
- Interplay of human ABCC11 transporter gene variants with axillary skin microbiome functional genomics.Scientific reports · 2024Article
- Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor.Human cell · 2024Article
- Objective Odor Assessment in Patients with Osmidrosis.Plastic and reconstructive surgery. Global open · 2022Article
- Role of Genetic Variation in ABC Transporters in Breast Cancer Prognosis and Therapy Response.International journal of molecular sciences · 2020Article
- The specific biochemistry of human axilla odour formation viewed in an evolutionary context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Overcoming imatinib resistance conferred by theOncotarget · 2017Article
- Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant.The pharmacogenomics journal · 2016Article
- Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human ABCC11 Gene: Clinical Practice and Basic Scientific Evidence.BioMed research international · 2016Review
- Regulation of the Axillary Osmidrosis-Associated ABCC11 Protein Stability by N-Linked Glycosylation: Effect of Glucose Condition.PloS one · 2016Article
- Glutathione-conjugated sulfanylalkanols are substrates for ABCC11 and γ-glutamyl transferase 1: a potential new pathway for the formation of odorant precursors in the apocrine sweat gland.Experimental dermatology · 2014Article
- Functional polymorphisms of xenobiotics metabolizing enzymes-a research topic.Frontiers in genetics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell secretion is an important physiological process that ensures smooth metabolic activities and tissue repair as well as growth and immunological functions in the body. Apocrine secretion occurs when the secretory process is accomplished with a partial loss of cell cytoplasm. The secretory materials are contained within secretory vesicles and are released during secretion as cytoplasmic fragments into the glandular lumen or interstitial space. The recent finding that the non-synonymous single nucleotide polymorphisms (SNP) 538G > A (rs17822931; Gly180Arg) in the ABCC11 gene determines the type of earwax in humans has shed light on the novel function of this ABC (ATP-binding cassette) transporter in apocrine glands. The wild-type (Gly180) of ABCC11 is associated with wet-type earwax, axillary osmidrosis, and colostrum secretion from the mammary gland as well as the potential risk of mastopathy. Furthermore, the SNP (538G > A) in the ABCC11 gene is suggested to be a clinical biomarker for the prediction of chemotherapeutic efficacy. The aim of this review article is to provide an overview on the discovery and characterization of genetic polymorphisms in the human ABCC11 gene and to explain the impact of ABCC11 538G > A on the apocrine phenotype as well as the anthropological aspect of this SNP in the ABCC11 gene and patients' response to nucleoside-based chemotherapy.
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