ArticleFrontiers in endocrinology2012
Central urocortin 3 and type 2 corticotropin-releasing factor receptor in the regulation of energy homeostasis: critical involvement of the ventromedial hypothalamus.
Article in Frontiers in endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Entrance-sealing behavior in the home cage: a defensive response to potential threats linked to the serotonergic system and manifestation of repetitive/stereotypic behavior in mice.Frontiers in behavioral neuroscience · 2023Article
- Linking stress with urocortin in rats.Bioinformation · 2023Article
- Identification of MRAP protein family as broad-spectrum GPCR modulators.Clinical and translational medicine · 2022Article
- Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats.Diabetologia · 2022Article
- Article
- Urocortin 3 overexpression reduces ER stress and heat shock response in 3T3-L1 adipocytes.Scientific reports · 2021Article
- Centrally Projecting Edinger-Westphal Nucleus in the Control of Sympathetic Outflow and Energy Homeostasis.Brain sciences · 2021Review
- Hypothalamic perifornical Urocortin-3 neurons modulate defensive responses to a potential threat stimulus.iScience · 2021Article
- Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Frontiers in systems neuroscience · 2021Article
- Urocortin 3 Levels Are Impaired in Overweight Humans With and Without Type 2 Diabetes and Modulated by Exercise.Frontiers in endocrinology · 2019Article
- Metabolic Association between Leptin and the Corticotropin Releasing Hormone.Endocrine, metabolic & immune disorders drug targets · 2019Article
- The effect of Nesfatin-1 on food intake in neonatal chicks: role of CRFVeterinary research communications · 2018Article
- The CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response.Current molecular pharmacology · 2018Review
- Anatomical Organization of Urocortin 3-Synthesizing Neurons and Immunoreactive Terminals in the Central Nervous System of Non-Human Primates [Frontiers in neuroanatomy · 2017Article
- Stress-activated afferent inputs into the anterior parvicellular part of the paraventricular nucleus of the hypothalamus: Insights into urocortin 3 neuron activation.Brain research · 2015Article
- The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms.International journal of obesity (2005) · 2015Article
- Peripheral α2-β1 adrenergic interactions mediate the ghrelin response to brain urocortin 1 in rats.Psychoneuroendocrinology · 2014Article
- Nesfatin-1: role as possible new anti-obesity treatment.EXCLI journal · 2014Review
- CRF and urocortin peptides as modulators of energy balance and feeding behavior during stress.Frontiers in neuroscience · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The vital role of the corticotropin-releasing factor (CRF) peptide family in the brain in coordinating response to stress has been extensively documented. The effects of CRF are mediated by two G-protein-coupled receptors, type 1 and type 2 CRF receptors (CRF(1) and CRF(2)). While the functional role of CRF(1) in hormonal and behavioral adaptation to stress is well-known, the physiological significance of CRF(2) remains to be fully appreciated. Accumulating evidence has indicated that CRF(2) and its selective ligands including urocortin 3 (Ucn 3) are important molecular mediators in regulating energy balance. Ucn 3 is the latest addition of the CRF family of peptides and is highly selective for CRF(2). Recent studies have shown that central Ucn 3 is important in a number of homeostatic functions including suppression of feeding, regulation of blood glucose levels, and thermoregulation, thus reinforcing the functional role of central CRF(2) in metabolic regulation. The brain loci that mediate the central effects of Ucn 3 remain to be fully determined. Anatomical and functional evidence has suggested that the ventromedial hypothalamus (VMH), where CRF(2) is prominently expressed, appears to be instrumental in mediating the effects of Ucn 3 on energy balance, permitting Ucn 3-mediated modulation of feeding and glycemic control. Thus, the Ucn 3-VMH CRF(2) system is an important neural pathway in the regulation of energy homeostasis and potentially plays a critical role in energy adaptation in response to metabolic perturbations and stress to maintain energy balance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.