ArticleFrontiers in behavioral neuroscience2012
Disrupting neural activity related to awake-state sharp wave-ripple complexes prevents hippocampal learning.
Article in Frontiers in behavioral neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Lateralization of Hippocampal Dentate Spikes and Sharp-Wave Ripples in Urethane Anesthetized Rats Depends on Cholinergic Tone.Hippocampus · 2025Article
- Article
- Cross-strata co-occurrence of ripples with theta-frequency oscillations in the hippocampus of foraging rats.The Journal of physiology · 2024Article
- Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion.bioRxiv : the preprint server for biology · 2023Article
- Experience alters hippocampal and cortical network communication via a KIBRA-dependent mechanism.Cell reports · 2023Article
- Ripples in macaque V1 and V4 are modulated by top-down visual attention.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Imagination as a fundamental function of the hippocampus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Disrupting ripples: Methods, results, and caveats in closed-loop approaches in rodents.Journal of sleep research · 2022Review
- A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations.Nature communications · 2022Review
- Rhythmic Memory Consolidation in the Hippocampus.Frontiers in neural circuits · 2022Article
- Recognition of post-learning alteration of hippocampal ripples by convolutional neural network differs in the wild-type and AD mice.Scientific reports · 2021Article
- Learning differentially shapes prefrontal and hippocampal activity during classical conditioning.eLife · 2021Article
- Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice.Neuron · 2021Article
- Effects of Spatial Memory Processing on Hippocampal Ripples.Frontiers in neurology · 2021Article
- Causal Contribution of Awake Post-encoding Processes to Episodic Memory Consolidation.Current biology : CB · 2020Article
- Potential factors influencing replay across CA1 during sharp-wave ripples.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Sharp-wave ripple features in macaques depend on behavioral state and cell-type specific firing.Hippocampus · 2020Article
- Age-associated changes in waking hippocampal sharp-wave ripples.Hippocampus · 2020Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Oscillations in hippocampal local-field potentials (LFPs) reflect the crucial involvement of the hippocampus in memory trace formation: theta (4-8 Hz) oscillations and ripples (~200 Hz) occurring during sharp waves are thought to mediate encoding and consolidation, respectively. During sharp wave-ripple complexes (SPW-Rs), hippocampal cell firing closely follows the pattern that took place during the initial experience, most likely reflecting replay of that event. Disrupting hippocampal ripples using electrical stimulation either during training in awake animals or during sleep after training retards spatial learning. Here, adult rabbits were trained in trace eyeblink conditioning, a hippocampus-dependent associative learning task. A bright light was presented to the animals during the inter-trial interval (ITI), when awake, either during SPW-Rs or irrespective of their neural state. Learning was particularly poor when the light was presented following SPW-Rs. While the light did not disrupt the ripple itself, it elicited a theta-band oscillation, a state that does not usually coincide with SPW-Rs. Thus, it seems that consolidation depends on neuronal activity within and beyond the hippocampus taking place immediately after, but by no means limited to, hippocampal SPW-Rs.
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