ArticleFrontiers in integrative neuroscience2012
Transsynaptic modality codes in the brain: possible involvement of synchronized spike timing, microRNAs, exosomes and epigenetic processes.
Article in Frontiers in integrative neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- The Coding and Small Non-coding Hippocampal Synaptic RNAome.Molecular neurobiology · 2021Article
- Diagnostic and therapeutic potentials of exosomes in CNS diseases.Brain research · 2015Review
- Exosomes as Novel Regulators of Adult Neurogenic Niches.Frontiers in cellular neuroscience · 2015Review
- Intercellular Signaling in Cancer-the SMT and TOFT Hypotheses, Exosomes, Telocytes and Metastases: Is the Messenger in the Message?Journal of Cancer · 2015Review
- Information handling by the brain: proposal of a new "paradigm" involving the roamer type of volume transmission and the tunneling nanotube type of wiring transmission.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- The role of epigenetic-related codes in neurocomputation: dynamic hardware in the brain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Molecular mechanisms for the inheritance of acquired characteristics-exosomes, microRNA shuttling, fear and stress: Lamarck resurrected?Frontiers in genetics · 2014Article
- Epigenetic aspects of telocytes/cordocytes: jacks of all trades, masters of most.Frontiers in cellular neuroscience · 2014Article
- Telocytes, exosomes, gap junctions and the cytoskeleton: the makings of a primitive nervous system?Frontiers in cellular neuroscience · 2014Article
- Exosomes in the gut.Frontiers in immunology · 2014Review
- Life without glutamate: the epigenetic effects of glutamate deletion.Frontiers in molecular neuroscience · 2014Article
- Methods for the extraction and RNA profiling of exosomes.World journal of methodology · 2013Article
- Interactions between the spike code and the epigenetic code during information processing in the brain.Frontiers in molecular neuroscience · 2013Article
- Spike dynamic and epigenetic malfunctions in epilepsy: a tale of two codes.Frontiers in neurology · 2013Article
- Hypotheses concerning how Otx2 makes its incredible journey: a hitchhiker on the road to Rome?Frontiers in molecular neuroscience · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper surveys two different mechanisms by which a presynaptic cell can modulate the structure and function of the postsynaptic cell. We first present the evidence that this occurs, and then discuss two mechanisms that could bring this about. The first hypothesis relates to the long lasting effects that the spike patterns of presynaptic axons may exert by modulating activity-inducible programs in postsynaptic cells. The second hypothesis is based on recently obtained evidence that, the afferent neuron at the neuromuscular junction buds off exosomes at its synapse and carries a cargo of Wg and Evi, which are large molecular transsynaptic signaling agents (LMTSAs). Further evidence indicates that many types of neurons bud off exosomes containing payloads of various lipids, proteins, and types of RNA. The evidence suggests that they are transmitted across the synapse and are taken up by the postsynaptic structure either by perisynaptic or exosynaptic mechanisms, thus mediating the transfer of information between neurons. To date, the molecular hypothesis has been limited to local interactions within the synapse of concern. In this paper, we explore the possibility that this represents a mechanism for information transfer involving the postsynaptic neuron as a whole. This entails a review of the known functions of these molecules in neuronal physiology, together with an estimate of the possible types of information they could carry and how they might affect neurocomputations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.