ArticleFrontiers in neural circuits2012
Ionotropic receptors at hippocampal mossy fibers: roles in axonal excitability, synaptic transmission, and plasticity.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Protocol for whole-cell patch-clamp recording and post hoc identification of hippocampal CA2 pyramidal neurons in adult mouse brain slices.STAR protocols · 2026Article
- Effects of a high-fat diet on cognition and brain distribution of intranasal insulin in E3 and E4 male and female mice.Scientific reports · 2024Article
- Physiological signature of a novel potentiator of AMPA receptor signalling.Molecular and cellular neurosciences · 2018Article
- Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons.Scientific reports · 2016Article
- Impact of single-site axonal GABAergic synaptic events on cerebellar interneuron activity.The Journal of general physiology · 2015Article
- Neuronal gamma-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA.Frontiers in cellular neuroscience · 2015Article
- Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway.Neuron · 2014Article
- Distribution of glycine receptors on the surface of the mature calyx of Held nerve terminal.Frontiers in neural circuits · 2014Article
- Structure, function, and plasticity of hippocampal dentate gyrus microcircuits.Frontiers in neural circuits · 2014Article
- Target-cell-specific short-term plasticity in local circuits.Frontiers in synaptic neuroscience · 2013Review
- Mixed neurotransmission in the hippocampal mossy fibers.Frontiers in cellular neuroscience · 2013Review
- Novel functions of GABA signaling in adult neurogenesis.Frontiers in biology · 2013Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
Dentate granule cells process information from the enthorinal cortex en route to the hippocampus proper. These neurons have a very negative resting membrane potential and are relatively silent in the slice preparation. They are also subject to strong feed-forward inhibition. Their unmyelinated axon or mossy fiber ramifies extensively in the hilus and projects to stratum lucidum where it makes giant en-passant boutons with CA3 pyramidal neurons. There is compelling evidence that mossy fiber boutons express presynaptic GABA(A) receptors, which are commonly found in granule cell dendrites. There is also suggestive evidence for the presence of other ionotropic receptors, including glycine, NMDA, and kainate receptors, in mossy fiber boutons. These presynaptic receptors have been proposed to lead to mossy fiber membrane depolarization. How this phenomenon alters the excitability of synaptic boutons, the shape of presynaptic action potentials, Ca(2+) influx and neurotransmitter release has remained elusive, but high-resolution live imaging of individual varicosities and direct patch-clamp recordings have begun to shed light on these phenomena. Presynaptic GABA(A) and kainate receptors have also been reported to facilitate the induction of long-term potentiation at mossy fiber-CA3 synapses. Although mossy fibers are highly specialized, some of the principles emerging at this connection may apply elsewhere in the CNS.
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