Evidence map›Paper›PMID 23315914›Full record

ArticleHepatology (Baltimore, Md.)2013

A global view of hepatitis C: physician knowledge, opinions, and perceived barriers to care.

Christopher E McGowan, Ali Monis, Bruce R Bacon, Josep Mallolas, Fernando L Goncales, Ioannis Goulis, Fred Poordad, Nezam Afdhal, Stefan Zeuzem, Teerha Piratvisuth and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Hepatology (Baltimore, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Article
  7. Article
  8. Article
  9. [Proper patient education improves hepatitis C patients' disease-related knowledge and antiviral treatment acceptance in rural China].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018
    Article
  10. Awareness and knowledge of hepatitis C among health care providers and the public: A scoping review.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2018
    Article
  11. Review
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  14. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 12 institutions in 8 countries.

Christopher E McGowanUNC Liver Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ali Monis
Bruce R Bacon
Josep Mallolas
Fernando L Goncales
Ioannis Goulis
Fred Poordad
Nezam Afdhal
Stefan Zeuzem
Teerha Piratvisuth
Patrick Marcellin
Michael W Fried
Ain Shams University · EGAristotle University of Thessaloniki · GRBeth Israel Deaconess Medical Center · USCedars-Sinai Medical Center · USHôpital Beaujon · FRHospital Clínic de Barcelona · ESMedical Protective · USPrince of Songkla University · THSaint Louis University · USUniversidade Estadual de Campinas (UNICAMP) · BRUniversity Hospital Frankfurt · DEUniversity of North Carolina at Chapel Hill · US

Funding

UNC CLINICAL AND TRANSLATIONAL SCIENCE AWARD: BPCAUL1RR025747 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2008 to 2011
$44.6M
DIGESTIVE DISEASES EPIDEMIOLOGY TRAINING PROGRAMT32DK007634 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1990 to 2026
$7.4M
Mentoring Junior Faculty: Viral hepatitis Clinical ResearchK24DK066144 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRIED, MICHAEL W · 2004 to 2014
$1.5M
NCRR NIH HHS UL1 RR025747NCRR NIH HHS UL1RR025747NIDDK NIH HHS K24 DK066144NIDDK NIH HHS T32 DK007634NIDDK NIH HHS T32 DK07634
6 · The paper itself

Abstract

unlabelledChronic infection with the hepatitis C virus (HCV) is a leading cause of global morbidity and mortality. Although recent advances in antiviral therapy have led to significant improvements in treatment response rates, only a minority of infected patients are treated. Multiple barriers may impede the delivery of HCV therapy. The aim of this study was to identify perceived barriers to care, knowledge, and opinions among a global sample of HCV treatment providers. An international, multidisciplinary survey of HCV treatment providers was conducted. Each physician responded to a series of 214 questions concerning his or her practice characteristics, opinions regarding the state of HCV care, knowledge regarding HCV treatment, and perception of treatment barriers. A total of 697 physicians from 29 countries completed the survey. Overall, physicians viewed patient-level barriers as most significant, including fear of side effects and concerns regarding treatment duration and cost. There were distinct regional variations, with Central and Eastern European physicians citing government barriers as most important. In Latin America, the Middle East, and Africa, payer-level barriers, including lack of treatment coverage, were prominent. Overall, the perception of barriers was strongly associated with physician knowledge, experience, and region of origin, with the fewest barriers reported by Nordic physicians and the most reported by Middle Eastern and African physicians. Globally, physicians demonstrated deficits in basic treatment principles, including the role of viral kinetics and the management of treatment nonresponders. Two thirds of surveyed physicians believed that patients do not have adequate access to providers in their community.

conclusionBarriers to HCV treatment vary globally, though patient-level factors are viewed as most significant by treating physicians. Efforts to improve awareness, education, and specialist availability are needed.

Indexed as

Delivery of Health CareGlobal HealthHealth Knowledge, Attitudes, PracticeAntiviral AgentsData CollectionHealth Care CostsHealth Services AccessibilityHepatitis CHumansInternational CooperationPatient CompliancePerceptionPhysiciansAntiviral Agents

Identifiers

PMID23315914
PMCPMC3683983
OpenAlexW2035625315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.