Evidence map›Paper›PMID 23315747›Full record

ArticleApplied and environmental microbiology2013

Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria.

Niclas Engene, Sarath P Gunasekera, William H Gerwick, Valerie J Paul

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Niclas EngeneSmithsonian Marine Station at Fort Pierce, Fort Pierce, Florida, USA. engenen@si.edu
Sarath P Gunasekera
William H Gerwick
Valerie J Paul
Smithsonian Marine Station · USScripps Institution of Oceanography · US

Funding

Neurotoxins from Marine Algae and CyanobacteriaR01NS053398 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GERWICK, WILLIAM HENRY, MURRAY, THOMAS F · 2005 to 2015
$4.3M
Discovery of Anticancer Drugs from CyanophytesR01CA100851 · NCI · HENRY FORD HEALTH SYSTEM · PI VALERIOTE, FREDERICK AUGUSTUS · 2004 to 2013
$3.8M
NCI NIH HHS CA100851NCI NIH HHS R01 CA100851NINDS NIH HHS NS053398NINDS NIH HHS R01 NS053398
6 · The paper itself

Abstract

Benthic marine cyanobacteria are known for their prolific biosynthetic capacities to produce structurally diverse secondary metabolites with biomedical application and their ability to form cyanobacterial harmful algal blooms. In an effort to provide taxonomic clarity to better guide future natural product drug discovery investigations and harmful algal bloom monitoring, this study investigated the taxonomy of tropical and subtropical natural product-producing marine cyanobacteria on the basis of their evolutionary relatedness. Our phylogenetic inferences of marine cyanobacterial strains responsible for over 100 bioactive secondary metabolites revealed an uneven taxonomic distribution, with a few groups being responsible for the vast majority of these molecules. Our data also suggest a high degree of novel biodiversity among natural product-producing strains that was previously overlooked by traditional morphology-based taxonomic approaches. This unrecognized biodiversity is primarily due to a lack of proper classification systems since the taxonomy of tropical and subtropical, benthic marine cyanobacteria has only recently been analyzed by phylogenetic methods. This evolutionary study provides a framework for a more robust classification system to better understand the taxonomy of tropical and subtropical marine cyanobacteria and the distribution of natural products in marine cyanobacteria.

Indexed as

BiodiversityBiological ProductsCluster AnalysisCyanobacteriaDNA, BacterialDNA, RibosomalMolecular Sequence DataPhylogenyRNA, Ribosomal, 16SSeawaterSequence Analysis, DNATropical ClimateBiological ProductsDNA, BacterialDNA, RibosomalRNA, Ribosomal, 16S

Identifiers

PMID23315747
PMCPMC3592240
OpenAlexW2109561356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.