ArticleApplied and environmental microbiology2013
Influence of the vaginal microbiota on toxic shock syndrome toxin 1 production by Staphylococcus aureus.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Prevalence and characterization of Staphylococcus aureus isolated from patients with aerobic vaginitis in Shenzhen, Southern China.BMC microbiology · 2026Article
- Progress in interventions for vaginal microecology.Frontiers in cellular and infection microbiology · 2026Review
- Discovery of an antivirulence compound that targets the Staphylococcus aureus SaeRS two-component system to inhibit toxic shock syndrome toxin-1 production.The Journal of biological chemistry · 2024Article
- Vaginal community state types (CSTs) alter environmental cues and production of theJournal of bacteriology · 2024Article
- 17β-Estradiol Mediates Staphylococcus aureus Adhesion in Vaginal Epithelial Cells via Estrogen Receptor α-Associated Signaling Pathway.Current microbiology · 2023Article
- Inhibition of Toxic Shock Syndrome-AssociatedMicrobiology spectrum · 2023Article
- Interspecies Interactions within the Host: the Social Network of Group BInfection and immunity · 2023Review
- Development ofFrontiers in reproductive health · 2023Article
- The Association Between Onset of Staphylococcal Non-menstrual Toxic Shock Syndrome With Inducibility of Toxic Shock Syndrome Toxin-1 Production.Frontiers in microbiology · 2022Article
- Changes in the diversity of local cervical bacteria in women with cervical cancer receiving antineoplastic treatment.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health.Microbial cell factories · 2020Review
- Device-Associated Menstrual Toxic Shock Syndrome.Clinical microbiology reviews · 2020Review
- Roles of the vagina and the vaginal microbiota in urinary tract infection: evidence from clinical correlations and experimental models.GMS infectious diseases · 2020Review
- The murine vaginal microbiota and its perturbation by the human pathogen group B Streptococcus.BMC microbiology · 2018Article
- Complex ecological interactions of Staphylococcus aureus in tampons during menstruation.Scientific reports · 2018Article
- In Vitro Probiotic Properties of Lactobacillus salivarius MG242 Isolated from Human Vagina.Probiotics and antimicrobial proteins · 2018Article
- The effect of vaginal microbial communities on colonization by Staphylococcus aureus with the gene for toxic shock syndrome toxin 1 (TSST-1): a case-control study.Pathogens and disease · 2018Article
- Manipulation of Innate and Adaptive Immunity by Staphylococcal Superantigens.Pathogens (Basel, Switzerland) · 2018Review
- Vaginal Microbiomes Associated With Aerobic Vaginitis and Bacterial Vaginosis.Frontiers in public health · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Menstrual toxic shock syndrome (TSS) is a serious illness that afflicts women of premenopausal age worldwide and arises from vaginal infection by Staphylococcus aureus and concurrent production of toxic shock syndrome toxin-1 (TSST-1). Studies have illustrated the capacity of lactobacilli to reduce S. aureus virulence, including the capacity to suppress TSST-1. We hypothesized that an aberrant microbiota characteristic of pathogenic bacteria would induce the increased production of TSST-1 and that this might represent a risk factor for the development of TSS. A S. aureus TSST-1 reporter strain was grown in the presence of vaginal swab contents collected from women with a clinically healthy vaginal status, women with an intermediate status, and those diagnosed with bacterial vaginosis (BV). Bacterial supernatant challenge assays were also performed to test the effects of aerobic vaginitis (AV)-associated pathogens toward TSST-1 production. While clinical samples from healthy and BV women suppressed toxin production, in vitro studies demonstrated that Streptococcus agalactiae and Enterococcus spp. significantly induced TSST-1 production, while some Lactobacillus spp. suppressed it. The findings suggest that women colonized by S. aureus and with AV, but not BV, may be more susceptible to menstrual TSS and would most benefit from prophylactic treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.