ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2013
Multicellularity arose several times in the evolution of eukaryotes (response to DOI 10.1002/bies.201100187).
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 69 citations in OpenAlex.
- Molecular and Functional Convergences Associated with Complex Multicellularity in Eukarya.Molecular biology and evolution · 2025Article
- Stability of ecologically scaffolded traits during evolutionary transitions in individuality.Nature communications · 2024Article
- Is biofilm formation intrinsic to the origin of life?Environmental microbiology · 2023Article
- In search of a Drosophila core cellular network with single-cell transcriptome data.G3 (Bethesda, Md.) · 2022Article
- Regulation of sedimentation rate shapes the evolution of multicellularity in a close unicellular relative of animals.PLoS biology · 2022Article
- Evolution of glutamatergic signaling and synapses.Neuropharmacology · 2021Review
- Evolution of Reproductive Division of Labor - Lessons Learned From the Social AmoebaFrontiers in cell and developmental biology · 2021Article
- Evolution of default genetic control mechanisms.PloS one · 2021Article
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- Symbiotic Origin of Apoptosis.Results and problems in cell differentiation · 2020Article
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- From tumors to species: a SCANDAL hypothesis.Biology direct · 2019Article
- Trait heritability in major transitions.BMC biology · 2018Article
- Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion.Nature communications · 2018Article
- New genomic data and analyses challenge the traditional vision of animal epithelium evolution.BMC genomics · 2018Article
- Kin Discrimination in Protists: From Many Cells to Single Cells and Backwards.The Journal of eukaryotic microbiology · 2016Article
- The diversification of the basic leucine zipper family in eukaryotes correlates with the evolution of multicellularity.BMC evolutionary biology · 2016Article
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2 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The cellular slime mold Dictyostelium has cell-cell connections similar in structure, function, and underlying molecular mechanisms to animal epithelial cells. These similarities form the basis for the proposal that multicellularity is ancestral to the clade containing animals, fungi, and Amoebozoa (including Dictyostelium): Amorphea (formerly "unikonts"). This hypothesis is intriguing and if true could precipitate a paradigm shift. However, phylogenetic analyses of two key genes reveal patterns inconsistent with a single origin of multicellularity. A single origin in Amorphea would also require loss of multicellularity in each of the many unicellular lineages within this clade. Further, there are numerous other origins of multicellularity within eukaryotes, including three within Amorphea, that are not characterized by these structural and mechanistic similarities. Instead, convergent evolution resulting from similar selective pressures for forming multicellular structures with motile and differentiated cells is the most likely explanation for the observed similarities between animal and dictyostelid cell-cell connections.
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